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Completion of all BHR modules was low (6%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Targeted ad placement, culturally tailored enrollment messaging, and culturally tailored BHR websites increased enrollment of Latino participants in BHR, but did not translate to increased module completion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Culturally tailored social marketing and website improvements were implemented.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The efforts enrolled 5662 Latino individuals in 12.5 months.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The number of Latino Brain Health Registry (BHR) participants increased by 122.7%.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>We failed to adequately enroll female Latinos and Latinos with lower education.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Future work will 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