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We evaluate the Care Ecosystem (CE) collaborative dementia care program on medication use among community\u2010dwelling persons living with dementia (PLWD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Secondary analysis of a randomized clinical trial (RCT) comparing CE to usual care (UC) on changes in PIMs, over 12 months between March 2015 and May 2020. Secondary outcomes included change in number of medications, clinically relevant PIMs, and anti\u2010dementia medications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 804 PLWD, <jats:italic>N<\/jats:italic>\u00a0=\u00a0490 had complete medication data. The CE resulted in significantly fewer PIMs compared to UC (\u22120.35; 95% CI, \u22120.49 to \u22120.20; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001). Number needed to prevent an increase in 1 PIM was 3. Total medications, PIMs for dementia or cognitive impairment, CNS\u2010active PIMs, anticholinergics, benzodiazepines, and opioids were also fewer. Anti\u2010dementia medication regimens were modified more frequently.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The CE medication review intervention embedded in collaborative dementia care optimized medication use among PLWD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Compared to usual care (UC), the Care Ecosystem (CE) medication review intervention prevented increases in potentially inappropriate medications (PIMs).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Use of anticholinergics,\u00a0benzodiazepines, and opioids were significantly reduced, with a trend for antipsychotics.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Anti\u2010dementia medications were adjusted more frequently.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The CE medication review intervention embedded in collaborative dementia care optimized medication use.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.12808","type":"journal-article","created":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T07:22:34Z","timestamp":1667546554000},"page":"1865-1875","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Effect of collaborative dementia care on potentially inappropriate medication use: Outcomes from the Care Ecosystem randomized clinical trial"],"prefix":"10.1002","volume":"19","author":[{"given":"Amy K.","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy University of California  San Francisco California USA"},{"name":"Memory and Aging Center Department of Neurology UCSF Weill Institute for Neurosciences University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine L.","family":"Possin","sequence":"additional","affiliation":[{"name":"Memory and Aging Center Department of Neurology UCSF Weill Institute for Neurosciences University of California  San Francisco California USA"},{"name":"Global Brain Health Institute University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen M.","family":"Cook","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice and Science University of Nebraska Medical Center  Omaha Nebraska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shalini","family":"Lynch","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Dulaney","sequence":"additional","affiliation":[{"name":"Memory and Aging Center Department of Neurology UCSF Weill Institute for Neurosciences University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer J.","family":"Merrilees","sequence":"additional","affiliation":[{"name":"Memory and Aging Center Department of Neurology UCSF Weill Institute for Neurosciences University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Braley","sequence":"additional","affiliation":[{"name":"Division of Geriatrics Gerontology, and Palliative Medicine Department of Internal Medicine University of Nebraska Medical Center  Omaha Nebraska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel E.","family":"Kiekhofer","sequence":"additional","affiliation":[{"name":"Memory and Aging Center Department of Neurology UCSF Weill Institute for Neurosciences University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Bonasera","sequence":"additional","affiliation":[{"name":"Division of Geriatrics Gerontology, and Palliative Medicine Department of Internal Medicine University of Nebraska Medical Center  Omaha Nebraska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel E.","family":"Allen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winston","family":"Chiong","sequence":"additional","affiliation":[{"name":"Memory and Aging Center Department of Neurology UCSF Weill Institute for Neurosciences University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy M.","family":"Clark","sequence":"additional","affiliation":[{"name":"Division of Geriatrics Gerontology, and Palliative Medicine Department of Internal Medicine University of Nebraska Medical Center  Omaha Nebraska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Feuer","sequence":"additional","affiliation":[{"name":"Memory and Aging Center Department of Neurology UCSF Weill Institute for Neurosciences University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Ewalt","sequence":"additional","affiliation":[{"name":"Division of Geriatrics Gerontology, and Palliative Medicine Department of Internal Medicine University of Nebraska Medical Center  Omaha Nebraska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elan L.","family":"Guterman","sequence":"additional","affiliation":[{"name":"Memory and Aging Center Department of Neurology UCSF Weill Institute for Neurosciences University of California  San Francisco California USA"},{"name":"Philip R. 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