{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:48:54Z","timestamp":1790869734648,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T00:00:00Z","timestamp":1666656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The credibility of model\u2010based economic evaluations of Alzheimer's disease (AD) interventions is central to appropriate decision\u2010making in a policy context. We report on the International PharmacoEconomic Collaboration on Alzheimer's Disease (IPECAD) Modeling Workshop Challenge.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two common benchmark scenarios, for the hypothetical treatment of AD mild cognitive impairment (MCI) and mild dementia, were developed jointly by 29 participants. Model outcomes were summarized, and cross\u2010comparisons were discussed during a structured workshop.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A broad concordance was established among participants. Mean 10\u2010year restricted survival and time in MCI in the control group ranged across 10 MCI models from 6.7 to 9.5 years and 3.4 to 5.6 years, respectively; and across 4 mild dementia models from 5.4 to 7.9 years (survival) and 1.5 to 4.2 years (mild dementia).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The model comparison increased our understanding of methods, data used, and disease progression. We established a collaboration framework to assess cost\u2010effectiveness outcomes, an important step toward transparent and credible AD models.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.12811","type":"journal-article","created":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T00:25:15Z","timestamp":1666743915000},"page":"1800-1820","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Cost\u2010effectiveness models for Alzheimer's disease and related dementias: IPECAD modeling workshop cross\u2010comparison challenge"],"prefix":"10.1002","volume":"19","author":[{"given":"Ron L.H.","family":"Handels","sequence":"first","affiliation":[{"name":"Maastricht University Department of Psychiatry and Neuropsychology Alzheimer Centre Limburg School for Mental Health and Neurosciences  Maastricht The Netherlands"},{"name":"Karolinska Institutet Department for Neurobiology, Care Sciences and Society Center for Alzheimer Research Division of Neurogeriatrics  Solna Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Green","sequence":"additional","affiliation":[{"name":"Karolinska Institutet Department for Neurobiology, Care Sciences and Society Center for Alzheimer Research Division of Neurogeriatrics  Solna Sweden"},{"name":"Health Economics Group University of Exeter College of Medicine and Health University of Exeter  Exeter UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Gustavsson","sequence":"additional","affiliation":[{"name":"Karolinska Institutet Department for Neurobiology, Care Sciences and Society Center for Alzheimer Research Division of Neurogeriatrics  Solna Sweden"},{"name":"Quantify Research Hantverkargatan 8  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William L.","family":"Herring","sequence":"additional","affiliation":[{"name":"RTI Health Solutions, Research Triangle Park  North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bengt","family":"Winblad","sequence":"additional","affiliation":[{"name":"Karolinska Institutet Department for Neurobiology, Care Sciences and Society Center for Alzheimer Research Division of Neurogeriatrics  Solna Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Wimo","sequence":"additional","affiliation":[{"name":"Karolinska Institutet Department for Neurobiology, Care Sciences and Society Center for Alzheimer Research Division of Neurogeriatrics  Solna Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Sk\u00f6ldunger","sequence":"additional","affiliation":[{"name":"Karolinska Institutet Department for Neurobiology, Care Sciences and Society Center for Alzheimer Research Division of Neurogeriatrics  Solna Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Karlsson","sequence":"additional","affiliation":[{"name":"Karolinska Institutet Department for Neurobiology, Care Sciences and Society Center for Alzheimer Research Division of Neurogeriatrics  Solna Sweden"},{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet  Solna Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Anderson","sequence":"additional","affiliation":[{"name":"Care Policy Evaluation Centre London School of Economics  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Belger","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company (UK)  Bracknell UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Br\u00fcck","sequence":"additional","affiliation":[{"name":"Erasmus MC University Medical Center Department of Public Health  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Espinosa","sequence":"additional","affiliation":[{"name":"Medicus Economics LLC  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakub P.","family":"Hl\u00e1vka","sequence":"additional","affiliation":[{"name":"University of Southern California Leonard D. Schaeffer Center for Health Policy &amp; Economics  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Jutkowitz","sequence":"additional","affiliation":[{"name":"Department of Health Services Policy &amp; Practice, Brown University School of Public Health  Providence Rhode Island USA"},{"name":"Providence Veterans Affairs (VA) Medical Center Center of Innovation in Long Term Services and Supports  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei\u2010Jung","family":"Lin","sequence":"additional","affiliation":[{"name":"Center for the Evaluation of Value and Risk in Health Institute for Clinical Research and Health Policy Studies Tufts Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio Lopez","family":"Mendez","sequence":"additional","affiliation":[{"name":"Department of Health Services Policy &amp; Practice, Brown University School of Public Health  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Mar","sequence":"additional","affiliation":[{"name":"Osakidetza Basque Health Service Debagoiena Integrated Health Organisation Research Unit  Arrasate\u2010Mondrag\u00f3n Spain"},{"name":"Biodonostia Health Research Institute  Donostia\u2010San Sebasti\u00e1n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Shewmaker","sequence":"additional","affiliation":[{"name":"Department of Health Services Policy &amp; Practice, Brown University School of Public Health  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eldon","family":"Spackman","sequence":"additional","affiliation":[{"name":"University of Calgary Department of Community Health Sciences  Calgary Canada"},{"name":"O'Brien Institute of Public Health  Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Tafazzoli","sequence":"additional","affiliation":[{"name":"Evidera  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan","family":"Tysinger","sequence":"additional","affiliation":[{"name":"University of Southern California Leonard D. Schaeffer Center for Health Policy &amp; Economics  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linus","family":"J\u00f6nsson","sequence":"additional","affiliation":[{"name":"Karolinska Institutet Department for Neurobiology, Care Sciences and Society Center for Alzheimer Research Division of Neurogeriatrics  Solna Sweden"},{"name":"H. Lundbeck A\/S  Valby Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"IPECAD modeling workshop 2020 participants","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610218001291"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40273\u2010016\u20100392\u20101"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13561\u2010018\u20100192\u20108"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737167.2020.1822738"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2016.12.005"},{"key":"e_1_2_9_7_1","article-title":"Health\u2010economic modelling for Alzheimer's disease: expert perspectives","author":"Landeiro F","year":"2021","journal-title":"Alzheimers Dement"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472\u20106963\u201014\u20102"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1258\/135581907779497594"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1258\/jhsrp.2011.010133"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2012.04.012"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168\u20108227(00)00217\u20105"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2014.03.1721"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc07\u20109919"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2013.01.002"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2020.04.1832"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2016.10.016"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/0272989x20924007"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2018.02.002"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S142378"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2019.05.004"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010191055"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.2174\/1567205011310020011"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.2174\/1567205015666180119092427"},{"key":"e_1_2_9_26_1","unstructured":"AndersonR KnappM WittenbergR HandelsR SchottJM.Economic modelling of disease\u2010modifying therapies in Alzheimer's disease. London School of Economics and Political Science London UK 2018. Obtained from:https:\/\/www.lse.ac.uk\/cpec\/assets\/documents\/EconomicmodellingAD.pdf"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10198\u2010018\u20101001\u20103"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.15043"},{"key":"e_1_2_9_29_1","unstructured":"HerringW KeenanA MauskopfJ MichaelT WiegandF.The potential economic value of disease\u2010modifying treatments in Alzheimer's disease: patient\u2010level simulation of predementia symptom trajectories. 2017 ISPOR 22nd Annu Int Meet May 23 2017 Boston MA Value Heal 2017 May; 20(5)A12 n.d."},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trci.2018.01.001"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/geronb\/gbx147"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654\u2010022\u201000878\u20101"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010020\u201000737\u20109"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1159\/000265553"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv029"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2017.10.003"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/geronb\/gbs077"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010210060"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916\u2010019\u20101403\u20109"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40273\u2010016\u20100479\u20108"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.12811","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alz.12811","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.12811","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:36:05Z","timestamp":1759941365000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.12811"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,25]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1002\/alz.12811"],"URL":"https:\/\/doi.org\/10.1002\/alz.12811","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,25]]},"assertion":[{"value":"2021-07-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}