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We investigated the association between spermidine plasma levels and markers of brain aging (hippocampal volume, AD score, global cortical thickness [CT], and white matter hyperintensities [WMH]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Higher spermidine levels were significantly associated with lower hippocampal volume (\n                      <jats:italic>\u00df<\/jats:italic>\n                      \u00a0=\u00a0\u22120.076; 95% confidence interval [CI]: \u22120.13 to \u22120.02;\n                      <jats:italic>q<\/jats:italic>\n                      =\u00a00.026), higher AD score (\n                      <jats:italic>\u00df<\/jats:italic>\n                      \u00a0=\u00a00.118; 95% CI: 0.05 to 0.19;\n                      <jats:italic>q<\/jats:italic>\n                      =\u00a00.006), lower global CT (\n                      <jats:italic>\u00df<\/jats:italic>\n                      \u00a0=\u00a0\u22120.104; 95% CI: \u22120.17 to \u22120.04;\n                      <jats:italic>q<\/jats:italic>\n                      =\u00a00.014), but not WMH volume. Sensitivity analysis revealed no substantial changes after excluding participants with cancer, depression, or hemolysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Elevated spermidine plasma levels are associated with advanced brain aging and might serve as potential early biomarker for AD and vascular brain pathology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.12815","type":"journal-article","created":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T07:16:02Z","timestamp":1667373362000},"page":"1832-1840","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Association of spermidine plasma levels with brain aging in a population\u2010based study"],"prefix":"10.1002","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9160-1175","authenticated-orcid":false,"given":"Silke M.","family":"Wortha","sequence":"first","affiliation":[{"name":"Department of Neurology University Medicine Greifswald  Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Frenzel","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy University Medicine Greifswald  Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Bahls","sequence":"additional","affiliation":[{"name":"German Centre for Cardiovascular Research (DZHK) Partner Site Greifswald  Greifswald Germany"},{"name":"Department of Internal Medicine B University Medicine Greifswald  Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad","family":"Habes","sequence":"additional","affiliation":[{"name":"Neuroimage Analytics Laboratory and Biggs Institute Neuroimaging Core Glenn Biggs Institute for Neurodegenerative Disorders University of Texas Health Science Center at San Antonio  San Antonio Texas USA"},{"name":"Department of Radiology University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Wittfeld","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy University Medicine Greifswald  Greifswald Germany"},{"name":"German Centre for Neurodegenerative Diseases (DZNE) Site Rostock\/Greifswald  Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Van der Auwera","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy University Medicine Greifswald  Greifswald Germany"},{"name":"German Centre for Neurodegenerative Diseases (DZNE) Site Rostock\/Greifswald  Greifswald 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