{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T23:30:12Z","timestamp":1790983812503,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T00:00:00Z","timestamp":1667347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Updated estimates of the US Alzheimer's disease (AD) population, including under\u2010represented populations, are needed to improve clinical trial diversity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A step\u2010wise approach calculating prevalent numbers from clinical syndrome to biomarker\u2010positive mild cognitive impairment (MCI) due to AD and mild AD was developed, using age\u2010and\u2010race\/ethnicity\u2010stratified data where available.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The estimated percentage of Americans aged\u00a0\u2265\u00a065 years with MCI due to AD was 9.2% of non\u2010Hispanic Whites, 13.6% of non\u2010Hispanic Blacks, 11.1% Hispanics, and 9.7% other race\/ethnicities. The estimated percentage of Americans aged\u00a0\u2265\u00a065 years with mild dementia due to AD among non\u2010Hispanic Whites was 3.7%, non\u2010Hispanic Blacks 7.0%, Hispanics 5.3%, and 3.9% other race\/ethnicities. Of these early\u2010stage AD cases, few are likely diagnosed, ranging from 13% of prevalent non\u2010Hispanic Black cases to 27% of non\u2010Hispanic White cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Under\u2010representation in clinical trials may be improved by setting recruitment goals reflecting the diversity of the AD patient population and supporting efforts toward timely diagnosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.12822","type":"journal-article","created":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T13:08:36Z","timestamp":1667394516000},"page":"1841-1848","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Estimating prevalence of early Alzheimer's disease in the United States, accounting for racial and ethnic diversity"],"prefix":"10.1002","volume":"19","author":[{"given":"Cai","family":"Gillis","sequence":"first","affiliation":[{"name":"Biogen  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Montenigro","sequence":"additional","affiliation":[{"name":"Biogen  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Nejati","sequence":"additional","affiliation":[{"name":"Biogen  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Maserejian","sequence":"additional","affiliation":[{"name":"Biogen  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2009.11.2\/cqiu"},{"key":"e_1_2_6_3_1","first-page":"P25","volume-title":"Projections of the Size and Composition of the U.S. Population: 2014 to 2060","author":"SLaJM Colby","year":"2014"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12328"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2468\u20102667(21)00249\u20108"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.06.3063"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12362"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12638"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1994.03510370056032"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1997.00550230066019"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.15059"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.2973"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10040778"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/1077558707305409"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2015.12.007"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.3233\/jad\u2010150778"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2018.09.012"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.12179"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2016.04.002"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jrh.12155"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.0000000000004826"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.60.8.1119"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606\u2010018\u20104377\u2010y"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glab043"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trci.2019.04.003"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/mlr.0000000000001577"},{"key":"e_1_2_6_27_1","volume-title":"CDC WONDER On\u2010Line Database","year":"2015"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dadm.2015.12.002"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2021.5216"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1166(199906)14:6<481::AID-GPS959>3.0.CO;2-5"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.3233\/jad\u2010200786"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40120\u2010021\u201000272\u20101"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.0000000000002914"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.12267"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25948"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2018.4249"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.0000000000200358"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1532\u20105415.2001.49096.x"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.3233\/jad\u2010180992"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1177\/1533317520960874"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.12822","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alz.12822","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.12822","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:36:18Z","timestamp":1759941378000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.12822"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,2]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1002\/alz.12822"],"URL":"https:\/\/doi.org\/10.1002\/alz.12822","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,2]]},"assertion":[{"value":"2022-07-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}