{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T02:20:46Z","timestamp":1789179646604,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>There are limited data on prevalence of dementia in centenarians and near\u2010centenarians (C\/NC), its determinants, and whether the risk of dementia continues to rise beyond 100.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participant\u2010level data were obtained from 18 community\u2010based studies (<jats:italic>N<\/jats:italic>\u00a0=\u00a04427) in 11 countries that included individuals \u226595 years. A harmonization protocol was applied to cognitive and functional impairments, and a meta\u2010analysis was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age was 98.3 years (SD\u00a0=\u00a02.67); 79% were women. After adjusting for age, sex, and education, dementia prevalence was 53.2% in women and 45.5% in men, with risk continuing to increase with age. Education (OR 0.95;0.92\u20130.98) was protective, as was hypertension (odds ratio [OR] 0.51;0.35\u20130.74) in five studies. Dementia was not associated with diabetes, vision and hearing impairments, smoking, and body mass index (BMI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Among the exceptional old, dementia prevalence remains higher in the older participants. Education was protective against dementia, but other factors for dementia\u2010free survival in C\/NC remain to be understood.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.12828","type":"journal-article","created":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T08:46:17Z","timestamp":1669884377000},"page":"2265-2275","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Cognition, function, and prevalent dementia in centenarians and near\u2010centenarians: An individual participant data (IPD) meta\u2010analysis of 18 studies"],"prefix":"10.1002","volume":"19","author":[{"given":"Yvonne","family":"Leung","sequence":"first","affiliation":[{"name":"Centre for Healthy Brain Ageing (CHeBA) School of Psychiatry University of New South Wales (UNSW)  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nir","family":"Barzilai","sequence":"additional","affiliation":[{"name":"Albert Einstein College of Medicine  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Batko\u2010Szwaczka","sequence":"additional","affiliation":[{"name":"Department of Geriatrics School of Health Sciences in Katowice Medical University of Silesia  Katowice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Beker","sequence":"additional","affiliation":[{"name":"Alzheimer Center Amsterdam Department of Neurology Amsterdam Neuroscience Vrije Universiteit Amsterdam Amsterdam UMC  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"Boerner","sequence":"additional","affiliation":[{"name":"Department of Gerontology McCormack Graduate School University of Massachusetts Boston  Boston USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Brayne","sequence":"additional","affiliation":[{"name":"University of Cambridge  Cambridge United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Brodaty","sequence":"additional","affiliation":[{"name":"Centre for Healthy Brain Ageing (CHeBA) School of Psychiatry University of New South Wales (UNSW)  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen Siu\u2010Lan","family":"Cheung","sequence":"additional","affiliation":[{"name":"University of Hong Kong (HKU)  Hong Kong SAR Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda M.","family":"Corrada","sequence":"additional","affiliation":[{"name":"University of California  Irvine USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"Crawford","sequence":"additional","affiliation":[{"name":"Centre for Healthy Brain Ageing (CHeBA) School of Psychiatry University of New South Wales (UNSW)  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia A.","family":"Galbussera","sequence":"additional","affiliation":[{"name":"Laboratory of Geriatric Neuropsychiatry Department of Neuroscience Istituto di Ricerche Farmacologiche \u201cMario Negri\u201d IRCCS  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyuki","family":"Gondo","sequence":"additional","affiliation":[{"name":"Osaka University Graduate School of Human Sciences School of Human Sciences: Osaka  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henne","family":"Holstege","sequence":"additional","affiliation":[{"name":"Genomics of Neurodegenerative Diseases and Aging, Human Genetics Vrije Universiteit Amsterdam Amsterdam UMC location VUmc  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Hulsman","sequence":"additional","affiliation":[{"name":"Genomics of Neurodegenerative Diseases and Aging, Human Genetics Vrije Universiteit Amsterdam Amsterdam UMC location VUmc  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiko Lily","family":"Ishioka","sequence":"additional","affiliation":[{"name":"O.P. 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