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Amyloid and tau deposition were assessed using positron emission tomography. Contactin 5 protein and mRNA levels were measured in brain tissue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>CSF contactin 5 increases progressively in cognitively unimpaired individuals and is decreased in mild cognitive impairment and sAD. CSF contactin 5 correlates with sAD biomarkers and with synaptic markers. The rs1461684 G variant associates with faster disease progression in cognitively unimpaired subjects. Cortical full\u2010length and isoform 3 <jats:italic>CNTN5<\/jats:italic> mRNAs are decreased in the presence of the G allele and as a function of Consortium to Establish a Registry for Alzheimer's Disease stages.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The newly identified rs1461684 G variant associates with sAD risk, rate of disease progression, and gene expression. Contactin 5 protein and mRNA are affected particularly in the early stages of the disease<\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.12868","type":"journal-article","created":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T09:09:12Z","timestamp":1672391352000},"page":"2816-2830","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Characterization of the contactin 5 protein and its risk\u2010associated polymorphic variant throughout the Alzheimer's disease spectrum"],"prefix":"10.1002","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1101-8236","authenticated-orcid":false,"given":"Marina Tedeschi","family":"Dauar","sequence":"first","affiliation":[{"name":"Douglas Mental Health University Institute  Montr\u00e9al Canada"},{"name":"Centre for the Studies in the Prevention of Alzheimer's Douglas Mental Health University Institute  Montr\u00e9al Canada"},{"name":"McGill University  Montr\u00e9al 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