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Additive\u2010scale interactions were estimated using the relative excess risk due to interaction (RERI) statistic.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      PTSD, TBI, and\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b54 showed strong main\u2010effect associations with ADRD. RERI analysis revealed significant additive\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b54 interactions with PTSD and TBI in the EA cohort and TBI in the AA cohort. These additive interactions indicate that ADRD prevalence associated with PTSD and TBI increased with the number of inherited\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b54 alleles.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>PTSD and TBI history will be an important part of interpreting the results of ADRD genetic testing and doing accurate ADRD risk assessment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.12870","type":"journal-article","created":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T07:00:51Z","timestamp":1671692451000},"page":"2549-2559","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Alzheimer's disease and related dementias among aging veterans: Examining gene\u2010by\u2010environment interactions with post\u2010traumatic stress disorder and traumatic brain injury"],"prefix":"10.1002","volume":"19","author":[{"given":"Mark W.","family":"Logue","sequence":"first","affiliation":[{"name":"National Center for PTSD Behavioral Sciences Division VA Boston Healthcare System  Boston Massachusetts USA"},{"name":"Department of Psychiatry Boston University Chobanian &amp; 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