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Hypertension\u2010induced dementia presents more evidently in women, highlighting the relevance of sex differences in the impact of cardiovascular risk. We summarize each major antihypertensive drug class's effects on cognitive impairment and AD pathology, revealing how carbonic anhydrase inhibitors, diuretics modulating cerebral blood flow, have recently gained preclinical evidence as promising treatment against AD. We also report novel vascular biomarkers for AD and dementia risk, highlighting those\u00a0associated with hypertension and HHcy. Importantly, we propose that future studies should consider hypertension and HHcy as potential contributors to cognitive impairment, and that uncovering the underlying molecular mechanisms and biomarkers would aid in the identification of\u00a0preventive strategies.<\/jats:p>","DOI":"10.1002\/alz.12871","type":"journal-article","created":{"date-parts":[[2022,11,19]],"date-time":"2022-11-19T14:44:14Z","timestamp":1668869054000},"page":"671-695","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["Hypertension and hyperhomocysteinemia as modifiable risk factors for Alzheimer's disease and dementia: New evidence, potential therapeutic strategies, and biomarkers"],"prefix":"10.1002","volume":"19","author":[{"given":"Ashley","family":"Carey","sequence":"first","affiliation":[{"name":"Department of Neural Sciences Temple University Lewis Katz School of Medicine Alzheimer's Center at Temple  Philadelphia Pennsylvania 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