{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:15:52Z","timestamp":1790363752611,"version":"4.1.0"},"reference-count":72,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T00:00:00Z","timestamp":1672185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Glial fibrillary acidic protein (GFAP) is a promising candidate blood\u2010based biomarker for Alzheimer's disease (AD) diagnosis and prognostication. The timing of its disease\u2010associated changes, its clinical correlates, and biofluid\u2010type dependency will influence its clinical utility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We evaluated plasma, serum, and cerebrospinal fluid (CSF) GFAP in families with autosomal dominant AD (ADAD), leveraging the predictable age at symptom onset to determine changes by stage of disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Plasma GFAP elevations appear a decade before expected symptom onset, after amyloid beta (A\u03b2) accumulation and prior to neurodegeneration and cognitive decline. Plasma GFAP distinguished A\u03b2\u2010positive from A\u03b2\u2010negative ADAD participants and showed a stronger relationship with A\u03b2 load in asymptomatic than symptomatic ADAD. Higher plasma GFAP was associated with the degree and rate of neurodegeneration and cognitive impairment. Serum GFAP showed similar relationships, but these were less pronounced for CSF GFAP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings support a role for plasma GFAP as a clinical biomarker of A\u03b2\u2010related astrocyte reactivity that is associated with cognitive decline and neurodegeneration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Plasma glial fibrillary acidic protein (GFAP) elevations appear a decade before expected symptom onset in autosomal dominant Alzheimer's disease (ADAD).<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Plasma GFAP was associated to amyloid positivity in asymptomatic ADAD.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Plasma GFAP increased with clinical severity and predicted disease progression.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Plasma and serum GFAP carried similar information in ADAD, while cerebrospinal fluid GFAP did not.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.12879","type":"journal-article","created":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T07:58:34Z","timestamp":1672214314000},"page":"2790-2804","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":79,"title":["Plasma glial fibrillary acidic protein in autosomal dominant Alzheimer's disease: Associations with A\u03b2\u2010PET, neurodegeneration, and cognition"],"prefix":"10.1002","volume":"19","author":[{"given":"Pratishtha","family":"Chatterjee","sequence":"first","affiliation":[{"name":"Macquarie Medical School Macquarie University  North Ryde New South Wales Australia"},{"name":"School of Medical Sciences Edith Cowan University Sarich Neuroscience Research Institute  Nedlands Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Vermunt","sequence":"additional","affiliation":[{"name":"Neurochemistry Laboratory Department of Clinical Chemistry Amsterdam Neuroscience Amsterdam University Medical Centers  Vrije Universiteit Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian A.","family":"Gordon","sequence":"additional","affiliation":[{"name":"Department of Radiology Washington University School of Medicine  Saint Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Pedrini","sequence":"additional","affiliation":[{"name":"School of Medical Sciences Edith Cowan University Sarich Neuroscience Research Institute  Nedlands Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Boonkamp","sequence":"additional","affiliation":[{"name":"Neurochemistry Laboratory Department of Clinical Chemistry Amsterdam Neuroscience Amsterdam University Medical Centers  Vrije Universiteit Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola J.","family":"Armstrong","sequence":"additional","affiliation":[{"name":"Department of Mathematics &amp; Statistics Curtin University  Bentley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengjie","family":"Xiong","sequence":"additional","affiliation":[{"name":"Knight Alzheimer's Disease Research Center Washington University School of Medicine  St. Louis Missouri USA"},{"name":"Hope Center for Neurological Disorders Washington University School of Medicine  St. Louis Missouri USA"},{"name":"Division of Biostatistics Washington University School of Medicine  Saint Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhay K.","family":"Singh","sequence":"additional","affiliation":[{"name":"Macquarie Business School Macquarie University  North Ryde New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Biostatistics Washington University School of Medicine  Saint Louis Missouri USA"},{"name":"Department of Neurology Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid R.","family":"Sohrabi","sequence":"additional","affiliation":[{"name":"School of Medical Sciences Edith Cowan University Sarich Neuroscience Research Institute  Nedlands Western Australia Australia"},{"name":"Department of Biomedical Sciences Macquarie University  North Ryde New South Wales Australia"},{"name":"School of Psychiatry and Clinical Neurosciences University of Western Australia  Crawley Western Australia Australia"},{"name":"Australian Alzheimer's Research Foundation  Nedlands Western Australia Australia"},{"name":"Centre for Healthy Ageing Health Future Institute Murdoch University  Murdoch Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Taddei","sequence":"additional","affiliation":[{"name":"School of Medical Sciences Edith Cowan University Sarich Neuroscience Research Institute  Nedlands Western Australia Australia"},{"name":"Australian Alzheimer's Research Foundation  Nedlands Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Molloy","sequence":"additional","affiliation":[{"name":"Bowel Cancer and Biomarker Laboratory Kolling Institute The University of Sydney  St. Leonards New South Wales Australia"},{"name":"Australian Proteome Analysis Facility Macquarie University  North Ryde New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tammie L. 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