{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T10:52:24Z","timestamp":1785149544382,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T00:00:00Z","timestamp":1670371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>We investigated amyloid\u2010burden quantification in a mixed memory clinic population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>[<jats:sup>18<\/jats:sup>F]Florbetaben amyloid\u2010PET (positron emission tomography) scans of 348 patients were visually read and quantified using the Centiloid (CL) method. General linear models were used to assess CL differences across syndromic and etiological diagnosis. Linear mixed models were fitted to assess the predictive value of visual read (VR) and CL on longitudinal Mini\u2010Mental Status Examination (MMSE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>CL was associated with syndromic (<jats:italic>F<\/jats:italic>\u00a0=\u00a04.42, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.014) and etiological diagnosis (<jats:italic>F<\/jats:italic>\u00a0=\u00a0\u201012.66, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), with Alzheimer's disease (AD) patients showing the highest amyloid burden (62.9\u00a0\u00b1\u00a027.5), followed by dementia with Lewy bodies (DLB) (25.3\u00a0\u00b1\u00a035.5) and cardiovascular disease (CVD) (16.7\u00a0\u00b1\u00a024.5), and finally frontotemporal lobe degeneration (FTLD) (5.0\u00a0\u00b1\u00a017.22, <jats:italic>t<\/jats:italic>\u00a0=\u00a0\u201312.66, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). CL remained predictive of etiological diagnosis (<jats:italic>t<\/jats:italic>\u00a0=\u00a0 \u20132.41, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.017) within the VR+ population (<jats:italic>N<\/jats:italic>\u00a0=\u00a0157). VR was not a significant predictor of MMSE (<jats:italic>t<\/jats:italic>\u00a0=\u00a0\u20131.53, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.13) for the SCD population (<jats:italic>N<\/jats:italic>\u00a0=\u00a090), whereas CL was (<jats:italic>t<\/jats:italic>\u00a0=\u00a0\u20103.30, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The extent of amyloid pathology through quantification holds clinical value, potentially in the context of differential diagnosis as well as prognosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.12886","type":"journal-article","created":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T12:03:13Z","timestamp":1670414593000},"page":"2397-2407","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Quantification of [<sup>18<\/sup>F]florbetaben amyloid\u2010PET imaging in a mixed memory clinic population: The ABIDE project"],"prefix":"10.1002","volume":"19","author":[{"given":"Lyduine E.","family":"Collij","sequence":"first","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Amsterdam University Medical Center Amsterdam Neuroscience  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"Salvad\u00f3","sequence":"additional","affiliation":[{"name":"Barcelona\u03b2eta Brain Research Center (BBRC) Pasqual Maragall Foundation  Barcelona Spain"},{"name":"Clinical Memory Research Unit Department of Clinical Sciences Lund University  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arno","family":"de Wilde","sequence":"additional","affiliation":[{"name":"Department of Neurology Alzheimer Center Amsterdam Amsterdam Neuroscience Vrije Universiteit Amsterdam Amsterdam UMC  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Altomare","sequence":"additional","affiliation":[{"name":"Laboratory of Neuroimaging of Aging (LANVIE) University of Geneva  Geneva Switzerland"},{"name":"Memory Center Geneva University Hospitals  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahnaz","family":"Shekari","sequence":"additional","affiliation":[{"name":"Barcelona\u03b2eta Brain Research Center (BBRC) Pasqual Maragall Foundation  Barcelona Spain"},{"name":"IMIM (Hospital del Mar Medical Research Institute)  Barcelona Spain"},{"name":"Pompeu Fabra University  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Domingo","family":"Gispert","sequence":"additional","affiliation":[{"name":"Barcelona\u03b2eta Brain Research Center (BBRC) Pasqual Maragall Foundation  Barcelona Spain"},{"name":"IMIM (Hospital del Mar Medical Research Institute)  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Bioingenier\u00eda Biomateriales y Nanomedicina (CIBER\u2010BBN)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Bullich","sequence":"additional","affiliation":[{"name":"Life Molecular Imaging GmbH  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Stephens","sequence":"additional","affiliation":[{"name":"Life Molecular Imaging GmbH  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik","family":"Barkhof","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Amsterdam University Medical Center Amsterdam Neuroscience  Amsterdam The Netherlands"},{"name":"Centre for Medical Image Computing and Queen Square Institute of Neurology UCL  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Scheltens","sequence":"additional","affiliation":[{"name":"Department of Neurology Alzheimer Center Amsterdam Amsterdam Neuroscience Vrije Universiteit Amsterdam Amsterdam UMC  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Femke","family":"Bouwman","sequence":"additional","affiliation":[{"name":"Department of Neurology Alzheimer Center Amsterdam Amsterdam Neuroscience Vrije Universiteit Amsterdam Amsterdam UMC  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wiesje M.","family":"van der Flier","sequence":"additional","affiliation":[{"name":"Department of Neurology Alzheimer Center Amsterdam Amsterdam Neuroscience Vrije Universiteit Amsterdam Amsterdam UMC  Amsterdam The Netherlands"},{"name":"Department of Epidemiology &amp; Data Science Amsterdam Neuroscience Vrije Universiteit Amsterdam Amsterdam UMC  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.018"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70077-1"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2018.1346"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.2000"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-016-0228-4"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-020-05174-2"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000010256"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.119.235879"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2019.2214"},{"issue":"5","key":"e_1_2_8_11_1","first-page":"e662","article-title":"Association of beta\u2010amyloid level, clinical progression and longitudinal cognitive change in normal older individuals","volume":"96","author":"Kall LM","year":"2020","journal-title":"Neurology"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000006469"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000011214"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.07.003"},{"issue":"2","key":"e_1_2_8_15_1","article-title":"Multisite study of the relationships between antemortem [(11)C]PIB\u2010PET Centiloid values and postmortem measures of Alzheimer's disease neuropathology","volume":"15","author":"Joie R","year":"2018","journal-title":"Alzheimers Dement"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-020-00587-5"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2019.02.005"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww160"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(20)30314-8"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000008818"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2015.12.016"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2021.118775"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-022-05784-y"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dadm.2017.01.003"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-170850"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1109\/NSSMIC.2007.4437091"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(1950)3:1<32::AID-CNCR2820030106>3.0.CO;2-3"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-020-04942-4"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.118.211532"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2015.05.018"},{"key":"e_1_2_8_31_1","volume-title":"On behalf of the AMYPAD consortium. Visual assessment and Centiloid quantification across diagnostic groups: the AMYPAD project. EANM","author":"Lyduine E Collij CB","year":"2021"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.12216"},{"key":"e_1_2_8_33_1","unstructured":"AHEAD 3\u201045 Study: A Study to Evaluate Efficacy and Safety of Treatment With BAN2401 in Participants With Preclinical Alzheimer's Disease and Elevated Amyloid and Also in Participants With Early Preclinical Alzheimer's Disease and Intermediate Amyloid[Available from:https:\/\/ClinicalTrials.gov\/show\/NCT04468659"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3007941"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2021.41"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.055726"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.055940"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.113.120618"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.12886","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alz.12886","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.12886","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:54:13Z","timestamp":1759971253000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.12886"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,7]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1002\/alz.12886"],"URL":"https:\/\/doi.org\/10.1002\/alz.12886","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,7]]},"assertion":[{"value":"2022-07-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}