{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T04:56:06Z","timestamp":1790052966228,"version":"4.0.1"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,1,2]],"date-time":"2023-01-02T00:00:00Z","timestamp":1672617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Empathy relies on fronto\u2010cingular and temporal networks that are selectively vulnerable in behavioral variant frontotemporal dementia (bvFTD). This study modeled when in the disease process empathy changes begin, and how they progress.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Four hundred thirty\u2010one individuals with asymptomatic genetic FTD (<jats:italic>n<\/jats:italic>\u00a0=\u00a0114), genetic and sporadic bvFTD (<jats:italic>n<\/jats:italic>\u00a0=\u00a0317), and 163 asymptomatic non\u2010carrier controls were enrolled. In sub\u2010samples, we investigated empathy measured by the informant\u2010based Interpersonal Reactivity Index (IRI) at each disease stage and over time (<jats:italic>n<\/jats:italic>\u00a0=\u00a091), and its correspondence to underlying atrophy (<jats:italic>n<\/jats:italic>\u00a0=\u00a051).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Empathic concern (estimate\u00a0=\u00a04.38, 95% confidence interval [CI]\u00a0=\u00a02.79, 5.97; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) and perspective taking (estimate\u00a0=\u00a05.64, 95% CI\u00a0=\u00a03.81, 7.48; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) scores declined between the asymptomatic and very mild symptomatic stages regardless of pathogenic variant status. More rapid loss of empathy corresponded with subcortical atrophy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Loss of empathy is an early and progressive symptom of bvFTD that is measurable by IRI informant ratings and can be used to monitor behavior in neuropsychiatry practice and treatment trials.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.12898","type":"journal-article","created":{"date-parts":[[2023,1,2]],"date-time":"2023-01-02T04:49:07Z","timestamp":1672634947000},"page":"2842-2852","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Multisite ALLFTD study modeling progressive empathy loss from the earliest stages of behavioral variant frontotemporal dementia"],"prefix":"10.1002","volume":"19","author":[{"given":"Gianina","family":"Toller","sequence":"first","affiliation":[{"name":"Memory and Aging Center Department of Neurology University of California  San Francisco California 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Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Leger","sequence":"additional","affiliation":[{"name":"University of California  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Litvan","sequence":"additional","affiliation":[{"name":"University of California  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian R.","family":"Mackenzie","sequence":"additional","affiliation":[{"name":"University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria B.","family":"Pascual","sequence":"additional","affiliation":[{"name":"Houston Methodist Hospital  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliana M.","family":"Ramos","sequence":"additional","affiliation":[{"name":"University of California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katya","family":"Rascovsky","sequence":"additional","affiliation":[{"name":"University of Pennsylvania  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio C.","family":"Rojas","sequence":"additional","affiliation":[{"name":"Memory and Aging Center Department of Neurology University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam M.","family":"Staffaroni","sequence":"additional","affiliation":[{"name":"Memory and Aging Center Department of Neurology University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria C.","family":"Tartaglia","sequence":"additional","affiliation":[{"name":"University of Toronto  Ontario 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