{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T18:59:36Z","timestamp":1781895576274,"version":"3.54.5"},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T00:00:00Z","timestamp":1672358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>MGMT<\/jats:italic>, the gene coding for the DNA\u2010repair protein <jats:italic>O<\/jats:italic><jats:sup>6<\/jats:sup>\u2010methylguanine methyltransferase, which has been recently shown to be a risk factor for inherited forms of Alzheimer's disease (AD), notably among women, might also be linked to Western Pacific amyotrophic lateral sclerosis and Parkinsonism\u2010dementia complex (ALS\/PDC), one phenotype of which is an AD\u2010like dementia. Guam ALS\/PDC is strongly considered to be an environmental disorder caused by oral exposure to natural toxins (i.e., genotoxic\/epigenotoxic chemicals), notably methylazoxymethanol (MAM) that alkylates guanine to form <jats:italic>O<\/jats:italic><jats:sup>6<\/jats:sup>\u2010methylguanine, found in the seed of cycad plants traditionally used for food. Thus, the DNA\u2010repair protein MGMT might participate in both AD and in the AD\u2010related disorder ALS\/PDC.<\/jats:p>","DOI":"10.1002\/alz.12900","type":"journal-article","created":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T05:58:55Z","timestamp":1672379935000},"page":"2208-2210","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["MGMT, a risk factor for both genetic and environmental forms of dementia"],"prefix":"10.1002","volume":"19","author":[{"given":"Glen E.","family":"Kisby","sequence":"first","affiliation":[{"name":"Department of Neurology, School of Medicine College of Osteopathic Medicine of the Pacific\u2010Northwest  Lebanon Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heaton","family":"Oakes","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medicine College of Osteopathic Medicine of the Pacific\u2010Northwest  Lebanon Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Beckett","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medicine College of Osteopathic Medicine of the Pacific\u2010Northwest  Lebanon Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3994-2639","authenticated-orcid":false,"given":"Peter S.","family":"Spencer","sequence":"additional","affiliation":[{"name":"Oregon Institute of Occupational Health Sciences Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,30]]},"reference":[{"key":"e_1_2_1_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2022.03.019"},{"key":"e_1_2_1_4_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000262028.16738.64"},{"key":"e_1_2_1_4_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000262027.31623.b2"},{"key":"e_1_2_1_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2020.117185"},{"key":"e_1_2_1_4_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.61.2.131"},{"key":"e_1_2_1_4_7_1","first-page":"613","article-title":"O6\u2010Methylguanine\u2010DNA methyltransferase in pediatric primary brain tumors: relation to patient and tumor characteristics","volume":"7","author":"Bobola MS","year":"2001","journal-title":"Clin Cancer Res"},{"key":"e_1_2_1_4_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.752153"},{"key":"e_1_2_1_4_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020911"},{"key":"e_1_2_1_4_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0002\u20109440(10)61119\u20104"},{"key":"e_1_2_1_4_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003\u2010022\u201003312\u20100"},{"key":"e_1_2_1_4_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276\u2010022\u201000727\u2010x"},{"key":"e_1_2_1_4_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/15592294.2022.2115604"},{"key":"e_1_2_1_4_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13148\u2010021\u201001009\u20105"},{"key":"e_1_2_1_4_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12719"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.12900","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alz.12900","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.12900","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:37:02Z","timestamp":1759941422000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.12900"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,30]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1002\/alz.12900"],"URL":"https:\/\/doi.org\/10.1002\/alz.12900","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,30]]},"assertion":[{"value":"2022-11-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}