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Dementia"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Our objective was determining the optimal combinations of cerebrospinal fluid (CSF) biomarkers for predicting disease progression in Alzheimer's disease (AD) and other neurodegenerative diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We included 1,983 participants from three different cohorts with longitudinal cognitive and clinical data, and baseline CSF levels of A\u03b242, A\u03b240, phosphorylated tau at threonine\u2010181 (p\u2010tau), neurofilament light (NfL), neurogranin, \u03b1\u2010synuclein, soluble triggering receptor expressed on myeloid cells 2 (sTREM2), glial fibrillary acidic protein (GFAP), YKL\u201040, S100b, and interleukin 6 (IL\u20106) (Elecsys NeuroToolKit).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Change of modified Preclinical Alzheimer's Cognitive Composite (mPACC) in cognitively unimpaired (CU) was best predicted by p\u2010tau\/A\u03b242 alone (R\n                      <jats:sup>2<\/jats:sup>\n                      \u2265 0.31) or together with NfL (R\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a00.25), while p\u2010tau\/A\u03b242 (R\n                      <jats:sup>2<\/jats:sup>\n                      \u2265 0.19) was sufficient to accurately predict change of the Mini\u2010Mental State Examination (MMSE) in mild cognitive impairment (MCI) patients. P\u2010tau\/A\u03b242 (AUC \u2265 0.87) and p\u2010tau\/A\u03b242 together with NfL (AUC \u2265 0.75) were the best predictors of conversion to AD and all\u2010cause dementia, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>P\u2010tau\/A\u03b242 is sufficient for predicting progression in AD, with very high accuracy. Adding NfL improves the prediction of all\u2010cause dementia conversion and cognitive decline.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.12907","type":"journal-article","created":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T08:22:10Z","timestamp":1673943730000},"page":"2943-2955","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Optimal combinations of CSF biomarkers for predicting cognitive decline and clinical conversion in cognitively unimpaired participants and mild cognitive impairment patients: A multi\u2010cohort study"],"prefix":"10.1002","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5210-9230","authenticated-orcid":false,"given":"Gemma","family":"Salvad\u00f3","sequence":"first","affiliation":[{"name":"Clinical Memory Research Unit Department of Clinical Sciences Malm\u00f6 Lund University  Lund 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Center University of Wisconsin School of Medicine and Public Health Madison Wisconsin University of Wisconsin\u2010Madison  Madison Wisconsin USA"},{"name":"Wisconsin Alzheimer's Institute School of Medicine and Public Health University of Wisconsin\u2010Madison  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Stomrud","sequence":"additional","affiliation":[{"name":"Clinical Memory Research Unit Department of Clinical Sciences Malm\u00f6 Lund University  Lund Sweden"},{"name":"Memory Clinic Sk\u00e5ne University Hospital  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwendlyn","family":"Kollmorgen","sequence":"additional","affiliation":[{"name":"Roche Diagnostics GmbH  Penzberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Wild","sequence":"additional","affiliation":[{"name":"Roche Diagnostics GmbH  Penzberg 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