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However, the anchoring of biomarker research to clinical symptomatology is often based on short and insensitive cognitive screening. This gives the impression that cognitive symptoms occur relatively late and that their progression in the early stages of the disease is slow. A thorough cognitive assessment is a powerful tool and has a key role in the accurate and early diagnosis of dementia. It is very different from the cognitive testing usually seen in biomarker research and drug development. Yet the distinction between these approaches is unclear to many. This paper highlights the misconceptions around cognitive research in dementia and suggests a way forward to facilitate biomarker and drug development through the improved utility of cognitive assessment tools.<\/jats:p>","DOI":"10.1002\/alz.12909","type":"journal-article","created":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T14:12:55Z","timestamp":1673619175000},"page":"2175-2181","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The ambivalence toward neuropsychology in dementia research, diagnosis, and drug development: Myths and misconceptions"],"prefix":"10.1002","volume":"19","author":[{"given":"Mar\u00eda K.","family":"J\u00f3nsd\u00f3ttir","sequence":"first","affiliation":[{"name":"Reykjav\u00edk University  Reykjav\u00edk Iceland"},{"name":"Landspitali \u2013 The National University Hospital of Iceland (Memory Clinic)  Reykjav\u00edk Iceland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Harrison","sequence":"additional","affiliation":[{"name":"Metis Cognition Ltd., Kilmington Common Wiltshire  UK"},{"name":"Alzheimercentrum  Amsterdam the Netherlands"},{"name":"Institute of Psychiatry, Psychology &amp; Neuroscience, KCL  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krist\u00edn I.","family":"Hannesd\u00f3ttir","sequence":"additional","affiliation":[{"name":"Novartis Institute of Biomedical Research  Cambridge Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,1,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11065\u2010008\u20109054\u20101"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz099"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.008"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/09540261.2013.763341"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp\u20102014\u2010309582"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/1471301214539691"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1017\/S104161021500157X"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102016\u2010011146"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2017.04.005"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000269933"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889\u2010019\u20107010\u2010z"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afw189"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp\u20102014\u2010307662"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u20102010\u2010101407"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.14137"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654\u2010018\u20100418\u20104"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(09)70299\u20106"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002923"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010150128"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/alzrt222"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/acx021"},{"key":"e_1_2_7_24_1","unstructured":"Food and Drug Administration.Early Alzheimer's disease: developing drugs for treatment guidance for industry. 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