{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:03:34Z","timestamp":1790719414065,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,1,28]],"date-time":"2023-01-28T00:00:00Z","timestamp":1674864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Investigate associations between the LIfestyle for BRAin Health (LIBRA) risk score with odds of mild cognitive impairment (MCI) diagnosis and cognitive function, incorporating concussion history.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Former National Football League (NFL) players (<jats:italic>N<\/jats:italic>\u00a0=\u00a01050; mean age\u00a0=\u00a064.8\u00a0\u00b1\u00a09.0\u2010years) completed initial testing for integration of concussion history into LIBRA scores (i.e., modified\u2010LIBRA) and completed the Brief Test of Adult Cognition by Telephone (BTACT). Modified\u2010LIBRA score (including concussion history) associations with odds of MCI and cognitive dysfunction were assessed via logistic and linear regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The highest quartile LIBRA scores were six times more likely to have a diagnosis of MCI compared to the lowest quartile (OR\u00a0=\u00a06.27[3.61, 10.91], <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). Modified\u2010LIBRA scores significantly improved model fit for odds of MCI above original LIBRA scores (<jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup>(1)\u00a0=\u00a07.76, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.005) and accounted for a greater fraction of variance in executive function (\u0394<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00.02, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.003) and episodic memory (\u0394<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00.02, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Modified\u2010LIBRA score, incorporating concussion history, may help monitoring risk status in former contact sport athletes, by targeting modifiable, lifestyle\u2010related risk factors.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.12929","type":"journal-article","created":{"date-parts":[[2023,1,28]],"date-time":"2023-01-28T04:59:34Z","timestamp":1674881974000},"page":"3087-3097","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Incorporation of concussion history as part of the LIfestyle for BRAin Health (LIBRA) modifiable factors risk score and associations with cognition in older former National Football League players"],"prefix":"10.1002","volume":"19","author":[{"given":"Benjamin L.","family":"Brett","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Medical College of Wisconsin  Wauwatosa Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neelum T.","family":"Aggarwal","sequence":"additional","affiliation":[{"name":"Rush Alzheimer's Disease Center  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avinash","family":"Chandran","sequence":"additional","affiliation":[{"name":"Datalys Center for Sports Injury Research and Prevention  Indianapolis Indiana USA"},{"name":"Department of Exercise and Sport Science University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary Yukio","family":"Kerr","sequence":"additional","affiliation":[{"name":"Department of Exercise and Sport Science University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel R.","family":"Walton","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Virginia Commonwealth University School of Medicine  Richmond Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. D.","family":"DeFreese","sequence":"additional","affiliation":[{"name":"Department of Exercise and Sport Science University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin M.","family":"Guskiewicz","sequence":"additional","affiliation":[{"name":"Department of Exercise and Sport Science University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruben J.","family":"Echemendia","sequence":"additional","affiliation":[{"name":"Psychological and Neurobehavioral Associates, Inc., State College  Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"William P.","family":"Meehan","sequence":"additional","affiliation":[{"name":"Boston Children's Hospital  Boston Massachusetts USA"},{"name":"Department of Pediatrics and Orthopedics Harvard Medical School  Boston Massachusetts 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