{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T10:50:51Z","timestamp":1792752651735,"version":"4.5.0"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,1,23]],"date-time":"2023-01-23T00:00:00Z","timestamp":1674432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006636","name":"Forskningsr\u00e5det om H\u00e4lsa, Arbetsliv och V\u00e4lf\u00e4rd","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006636","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2020\u201001030"],"award-info":[{"award-number":["2020\u201001030"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>We evaluated markers of olfactory dysfunction (OD) for estimating hazard of dementia in older adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Mild (hyposmia) and severe (anosmia) OD was classified in a population\u2010based study of dementia\u2010free persons (SNAC\u2010K;\n                      <jats:italic>n<\/jats:italic>\n                      = 2473; mean age = 70 years) using the Sniffin sticks odor identification task. Combined variables were created for objective and subjective OD and for OD and\n                      <jats:italic>APOE<\/jats:italic>\n                      status. Hazard of dementia across 12 years was estimated with Cox regression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      OD was associated with increased hazard of dementia (2.01; 95% confidence interval [CI] 1.60\u20102.52), with the strongest association for anosmia (2.92; 95% CI 2.14\u20103.98). Results remained consistent after adjusting for potential confounders and across age and sex subgroups.\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b54 carriers with anosmia had the highest hazard of dementia (\u03b54: 6.95; 95% CI 4.16\u201011.62; \u03b54\/\u03b54: 19.84; 95% CI 6.17\u201063.78).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>OD is associated with increased risk of dementia, especially severe impairment in combination with genetic risk of Alzheimer's disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.12932","type":"journal-article","created":{"date-parts":[[2023,1,23]],"date-time":"2023-01-23T14:59:37Z","timestamp":1674485977000},"page":"3019-3027","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Markers of olfactory dysfunction and progression to dementia: A 12\u2010year population\u2010based study"],"prefix":"10.1002","volume":"19","author":[{"given":"Erika J","family":"Laukka","sequence":"first","affiliation":[{"name":"Aging Research Center Department of Neurobiology, Care Sciences and Society Karolinska Institutet and Stockholm University  Stockholm Sweden"},{"name":"Stockholm Gerontology Research Center  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Ekstr\u00f6m","sequence":"additional","affiliation":[{"name":"Aging Research Center Department of Neurobiology, Care Sciences and Society Karolinska Institutet and Stockholm University  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Larsson","sequence":"additional","affiliation":[{"name":"G\u00f6sta Ekman Laboratory, Department of Psychology Stockholm University  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Grande","sequence":"additional","affiliation":[{"name":"Aging Research Center Department of Neurobiology, Care Sciences and Society Karolinska Institutet and Stockholm University  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Fratiglioni","sequence":"additional","affiliation":[{"name":"Aging Research Center Department of Neurobiology, Care Sciences and Society Karolinska Institutet and Stockholm University  Stockholm Sweden"},{"name":"Stockholm Gerontology Research Center  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debora","family":"Rizzuto","sequence":"additional","affiliation":[{"name":"Aging Research Center Department of Neurobiology, Care Sciences and Society Karolinska Institutet and Stockholm University  Stockholm Sweden"},{"name":"Stockholm Gerontology Research Center  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-018-0097-5"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617713001409"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001132"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003558"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.15048"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2008.06.020"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2015.2952"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glx054"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.18.2307"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.7.1480"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/acr019"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70325-2"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2015.11.012"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-01508-7"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci11111391"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000006919"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/bju069"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glaa221"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004050050223"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-006-0173-0"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-018-5248-1"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016480310001411"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/13825589708256633"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12101"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12704"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/13825580903042684"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2012.02.047"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.14770"},{"key":"e_1_2_8_30_1","article-title":"Associations of olfactory impairment with all\u2010cause mortality: A systematic review and meta\u2010analysis","author":"Pang NYL","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/13803391003683070"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1159\/000381619"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001614"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.12932","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alz.12932","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.12932","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T13:15:42Z","timestamp":1759929342000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.12932"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,23]]},"references-count":32,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["10.1002\/alz.12932"],"URL":"https:\/\/doi.org\/10.1002\/alz.12932","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,23]]},"assertion":[{"value":"2022-09-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}