{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T10:34:17Z","timestamp":1792233257229,"version":"4.4.0"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T00:00:00Z","timestamp":1674086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30AG10161"],"award-info":[{"award-number":["P30AG10161"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30AG72975"],"award-info":[{"award-number":["P30AG72975"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG15819"],"award-info":[{"award-number":["R01AG15819"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG17917"],"award-info":[{"award-number":["R01AG17917"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2023,7]]},"abstract":"Abstract<\/jats:title>\n \n Introduction<\/jats:title>\n We assessed the association between visit\u2010to\u2010visit blood pressure variability (BPV) up to 12 years and subsequent dementia risk, and tested the modifying effect of antihypertensive medications.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We studied 2234 participants from two community\u2010based cohorts of older adults with normal cognition or mild cognitive impairment. Participants were followed through annual assessments for up to 27 years. Visit\u2010to\u2010visit BPV was quantified over 3, 6, 9, and 12 years, respectively.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Higher systolic BPV (SBPV) during 3, 6, 9, and 12 years was associated with a subsequent increased risk of dementia, with hazard ratios ranging from 1.02 (95% confidence interval [CI]: 1.01\u20131.04) to 1.10 (95% CI: 1.05\u20131.16). The association between SBPV and dementia risk was stronger among participants not taking calcium channel blockers (\n p<\/jats:italic>\n \u2010for interaction\u00a0<\u00a00.05).\n <\/jats:p>\n <\/jats:sec>\n \n Discussion<\/jats:title>\n Among older adults, long\u2010term exposure to higher visit\u2010to\u2010visit SBPV is associated with an increased risk of dementia later in life, and calcium channel blockers may modify this association.<\/jats:p>\n <\/jats:sec>\n \n Highlights<\/jats:title>\n \n \n \n Among adults aged\u00a0>65,\u00a0higher systolic blood pressure variability spanning 3\u201312 years is associated with an increased risk of dementia later in life.<\/jats:p>\n <\/jats:list-item>\n \n Single blood pressure measurement or mean blood pressure levels does not seem to associate with dementia risk among older adults.<\/jats:p>\n <\/jats:list-item>\n \n The association between systolic blood pressure variability and dementia risk is stronger among those not taking calcium channel blocker medications.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/alz.12935","type":"journal-article","created":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T09:40:04Z","timestamp":1674121204000},"page":"2966-2974","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Blood pressure variability, dementia, and role of antihypertensive medications in older adults"],"prefix":"10.1002","volume":"19","author":[{"given":"Simin","family":"Mahinrad","sequence":"first","affiliation":[{"name":"Department of Neurology Feinberg School of Medicine Northwestern University Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Bennett","sequence":"additional","affiliation":[{"name":"Department of Neurological Sciences and Rush Alzheimer's Disease Center Rush University Medical Center Chicago Illinois 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