{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T07:40:33Z","timestamp":1778139633429,"version":"3.51.4"},"reference-count":41,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,1,26]],"date-time":"2023-01-26T00:00:00Z","timestamp":1674691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R01AG066088"],"award-info":[{"award-number":["1R01AG066088"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 AG024904"],"award-info":[{"award-number":["U01 AG024904"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Identifying individuals who are most likely to accumulate tau and exhibit cognitive decline is critical for Alzheimer's disease (AD) clinical trials.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants (<jats:italic>N<\/jats:italic>\u00a0=\u00a0235) who were cognitively normal or with mild cognitive impairment from the Alzheimer's Disease Neuroimaging Initiative were stratified by a cutoff on the polygenic hazard score (PHS) at 65th percentile (above as high\u2010risk group and below as low\u2010risk group). We evaluated the associations between the PHS risk groups and tau positron emission tomography and cognitive decline, respectively. Power analyses estimated the sample size needed for clinical trials to detect differences in tau accumulation or cognitive change.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The high\u2010risk group showed faster tau accumulation and cognitive decline. Clinical trials using the high\u2010risk group would require a fraction of the sample size as trials without this inclusion criterion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Incorporating a PHS inclusion criterion represents a low\u2010cost and accessible way to identify potential participants for AD clinical trials.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.12952","type":"journal-article","created":{"date-parts":[[2023,1,26]],"date-time":"2023-01-26T12:18:39Z","timestamp":1674735519000},"page":"3078-3086","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A simple genetic stratification method for lower cost, more expedient clinical trials in early Alzheimer's disease: A preliminary study of tau PET and cognitive outcomes"],"prefix":"10.1002","volume":"19","author":[{"given":"Xin","family":"Wang","sequence":"first","affiliation":[{"name":"University of California  San Diego California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iris","family":"Broce","sequence":"additional","affiliation":[{"name":"University of California  San Diego California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuqi","family":"Qiu","sequence":"additional","affiliation":[{"name":"East China Normal University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kacie D.","family":"Deters","sequence":"additional","affiliation":[{"name":"University of California  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun Chieh","family":"Fan","sequence":"additional","affiliation":[{"name":"University of California  San Diego California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders M.","family":"Dale","sequence":"additional","affiliation":[{"name":"University of California  San Diego California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven D.","family":"Edland","sequence":"additional","affiliation":[{"name":"University of California  San Diego California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah J.","family":"Banks","sequence":"additional","affiliation":[{"name":"University of California  San Diego California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the Alzheimer's Disease Neuroimaging 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