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MMD patients scored significantly lower than controls in multiple cognitive tests. Revascularization increased CBF to the recipient brain territories as well as cognitive performance but produced no significant change in AD biomarker levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>These data suggest a link between accumulated reductions in CBF and cognitive decline, as well as a possible role of AD\u2010like pathological burden. Further studies in MMD will provide opportunities to explore new treatment strategies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.12958","type":"journal-article","created":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T07:47:49Z","timestamp":1676015269000},"page":"3316-3326","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Brain perfusion, cognition, and plasma Alzheimer's biomarkers in moyamoya disease"],"prefix":"10.1002","volume":"19","author":[{"given":"Xiang","family":"Zou","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Huashan Hospital, Fudan University  Shanghai China"},{"name":"Neurosurgical Institute of Fudan University  Shanghai China"},{"name":"Shanghai Clinical Medical Center of Neurosurgery  Shanghai China"},{"name":"Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration  Shanghai China"},{"name":"National Center for Neurological Disorders  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