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&amp;amp; Dementia"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Sex differences in dementia risk, and risk factor (RF) associations with dementia, remain uncertain across diverse ethno\u2010regional groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 29,850 participants (58% women) from 21 cohorts across six continents were included in an individual participant data meta\u2010analysis. Sex\u2010specific hazard ratios (HRs), and women\u2010to\u2010men ratio of hazard ratios (RHRs) for associations between RFs and all\u2010cause dementia were derived from mixed\u2010effect Cox models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Incident dementia occurred in 2089 (66% women) participants over 4.6 years (median). Women had higher dementia risk (HR, 1.12 [1.02, 1.23]) than men, particularly in low\u2010 and lower\u2010middle\u2010income economies. Associations between longer education and former alcohol use with dementia risk (RHR, 1.01 [1.00, 1.03] per year, and 0.55 [0.38, 0.79], respectively) were stronger for men than women; otherwise, there were no discernible sex differences in other RFs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Dementia risk was higher in women than men, with possible variations by country\u2010level income settings, but most RFs appear to work similarly in women and men.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.12962","type":"journal-article","created":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T07:02:22Z","timestamp":1676444542000},"page":"3365-3378","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":143,"title":["Sex differences in dementia risk and risk factors: Individual\u2010participant data analysis using 21 cohorts across six continents from the COSMIC consortium"],"prefix":"10.1002","volume":"19","author":[{"given":"Jessica","family":"Gong","sequence":"first","affiliation":[{"name":"The George Institute for Global Health University of New South Wales  Sydney Australia"},{"name":"The George Institute for Global Health Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie","family":"Harris","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health University of New South Wales  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren M.","family":"Lipnicki","sequence":"additional","affiliation":[{"name":"Centre for Healthy Brain Ageing (CHeBA) Discipline of Psychiatry and Mental Health Faculty of Medicine and Health UNSW Sydney  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erico","family":"Castro\u2010Costa","sequence":"additional","affiliation":[{"name":"Center for Studies in Public Health and Aging Rene Rachou Institute Oswaldo Cruz Foundation  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Fernanda","family":"Lima\u2010Costa","sequence":"additional","affiliation":[{"name":"Center for Studies in Public Health and Aging Rene Rachou Institute Oswaldo Cruz Foundation  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Breno S.","family":"Diniz","sequence":"additional","affiliation":[{"name":"UConn Center on Aging Department of Psychiatry School\u00a0of Medicine University of Connecticut Health Center  Farmington Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shifu","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Geriatric Psychiatry Shanghai Mental Health Centre Shanghai Jiaotong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard B.","family":"Lipton","sequence":"additional","affiliation":[{"name":"Department of Neurology Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mindy J.","family":"Katz","sequence":"additional","affiliation":[{"name":"Department of Neurology Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuiling","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Community Heath Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre\u2010Marie","family":"Preux","sequence":"additional","affiliation":[{"name":"Inserm U1094, IRD U270, Univ. 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