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The association of PRSA\u03b242 and CR with AD\/aMCI incidence was examined with COX models. Then we examined the additive interaction between PRSA\u03b242 and CR and the CR effect across participants with different PRSA\u03b242 levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Higher PRSA\u03b242 and CR were associated with a 33.9% higher risk and 8.3% less risk for AD\/aMCI, respectively. An additive interaction between PRSA\u03b242 and CR was observed. High CR was associated with 62.6% less risk of AD\/aMCI incidence only in the high\u2010PRSA\u03b242 group.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>A super\u2010additive effect of PRSA\u03b242 and CR on AD\/aMCI risk was observed. CR influence was evident in participants with high PRSA\u03b242.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.12980","type":"journal-article","created":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T00:11:01Z","timestamp":1678407061000},"page":"3794-3805","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Genetic propensity for cerebral amyloidosis and risk of mild cognitive impairment and Alzheimer's disease within a cognitive reserve framework"],"prefix":"10.1002","volume":"19","author":[{"given":"Niki","family":"Mourtzi","sequence":"first","affiliation":[{"name":"1st Department of Neurology Aiginition Hospital, National and Kapodistrian University of Athens Medical School  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sokratis","family":"Charisis","sequence":"additional","affiliation":[{"name":"1st Department of Neurology Aiginition Hospital, National and Kapodistrian University of Athens Medical School  Athens Greece"},{"name":"Department of Neurology University of Texas Health Science Center at San Antonio  San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angeliki","family":"Tsapanou","sequence":"additional","affiliation":[{"name":"1st Department of Neurology Aiginition Hospital, National and Kapodistrian University of Athens Medical School  Athens Greece"},{"name":"Department of Neurology, The Gertrude H. 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