{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T12:02:51Z","timestamp":1789646571415,"version":"4.0.0"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T00:00:00Z","timestamp":1676505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>The association between neuropathological changes and dementia among centenarians and nonagenarians remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      We examined brain tissue from 100 centenarians and 297 nonagenarians from\n                      <jats:italic>The 90+ Study<\/jats:italic>\n                      , a community\u2010based longitudinal study of aging. We determined the prevalence of 10 neuropathological changes and compared their associations with dementia and cognitive performance between centenarians and nonagenarians.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>A total of 59% of centenarians and 47% of nonagenarians had at least four neuropathological changes. In centenarians, neuropathological changes were associated with higher odds of dementia and, compared to nonagenarians, the odds were not attenuated. For each additional neuropathological change, the Mini\u2010Mental State Examination score was lower by 2 points for both groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Neuropathological changes continue to be strongly related to dementia in centenarians, highlighting the importance of slowing or preventing the development of multiple neuropathological changes in the aging brain to maintain cognitive health.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Individual and multiple neuropathological changes are frequent in centenarians.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>These neuropathological changes are strongly associated\u00a0with dementia.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>There is no attenuation of this association with age.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.12981","type":"journal-article","created":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T14:58:25Z","timestamp":1676559505000},"page":"3417-3425","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Study of neuropathological changes and dementia in 100 centenarians in The 90+ Study"],"prefix":"10.1002","volume":"19","author":[{"given":"Raumin S.","family":"Neuville","sequence":"first","affiliation":[{"name":"School of Medicine University of California, Irvine  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roshni","family":"Biswas","sequence":"additional","affiliation":[{"name":"Department of Neurology University of California, Irvine, Hewitt Hall  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chu\u2010Ching","family":"Ho","sequence":"additional","affiliation":[{"name":"Institute for Memory Impairments and Neurological Disorders University of California, Irvine  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed","family":"Bukhari","sequence":"additional","affiliation":[{"name":"Department of Pathology Stanford University  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Ahmad","family":"Sajjadi","sequence":"additional","affiliation":[{"name":"Department of Neurology University of California, Irvine, Hewitt Hall  Irvine California USA"},{"name":"Institute for Memory Impairments and Neurological Disorders University of California, Irvine  Irvine California USA"},{"name":"Department of Neurobiology &amp; Behavior University of California, Irvine, Gillespie NRF  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annlia","family":"Paganini\u2010Hill","sequence":"additional","affiliation":[{"name":"Department of Neurology University of California, Irvine, Hewitt Hall  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Montine","sequence":"additional","affiliation":[{"name":"Department of Pathology Stanford University  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda M.","family":"Corrada","sequence":"additional","affiliation":[{"name":"Department of Neurology University of California, Irvine, Hewitt Hall  Irvine California USA"},{"name":"Institute for Memory Impairments and Neurological Disorders University of California, Irvine  Irvine California USA"},{"name":"Department of Epidemiology University of California, Irvine, Anteater Instruction &amp; Research Offices (AIRB)  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia H.","family":"Kawas","sequence":"additional","affiliation":[{"name":"Department of Neurology University of California, Irvine, Hewitt Hall  Irvine California USA"},{"name":"Institute for Memory Impairments and Neurological Disorders University of California, Irvine  Irvine California USA"},{"name":"Department of Neurobiology &amp; Behavior University of California, Irvine, Gillespie NRF  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,16]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"Meyer J. Centenarians: 2010.Washington DC: US Dept of Commerce Economics and Statistics Administration US Census Bureau. 2012 Dec; 24."},{"key":"e_1_2_7_3_1","unstructured":"XuJ.Mortality among centenarians in the United States 2000\u20132014.NCHS Data Brief.2016;(233):1\u20108."},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000310773.65918.cd"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glr250"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2015.10.009"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-018-0558-5"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-181110"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0806142"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.2174\/156720512801322537"},{"issue":"101","key":"e_1_2_7_11_1","first-page":"S56","article-title":"The oldest old and the 90+ Study","volume":"4","author":"Kawas CH","year":"2008","journal-title":"Alzheimers Dement"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(86)90153-0"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0000000000000260"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.10.007"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-011-0910-3"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410300503"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz099"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-015-1509-x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004058"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/13803390600678038"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_2_7_22_1","unstructured":"Diagnostic and statistical manual of mental disorders 4th ed. 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