{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T18:10:12Z","timestamp":1775844612212,"version":"3.50.1"},"reference-count":50,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T00:00:00Z","timestamp":1677715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Cognitive impairment is common after severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) infection. However, associations between post\u2010hospital discharge risk factors and cognitive trajectories have not been explored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 1105 adults (mean age \u00b1 SD 64.9 \u00b1 9.9 years, 44% women, 63% White) with severe coronavirus disease 2019 (COVID\u201019) were evaluated for cognitive function 1 year after hospital discharge. Scores from cognitive tests were harmonized, and clusters of cognitive impairment were defined using sequential analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three groups of cognitive trajectories were observed during the follow\u2010up: no cognitive impairment, initial short\u2010term cognitive impairment, and long\u2010term cognitive impairment. Predictors of cognitive decline after COVID\u201019 were older age (<jats:italic>\u03b2<\/jats:italic>\u00a0=\u00a0\u22120.013, 95% CI =\u00a0\u22120.023;\u22120.003), female sex (<jats:italic>\u03b2<\/jats:italic>\u00a0=\u00a0\u22120.230, 95% CI\u00a0=\u00a0\u22120.413;\u22120.047), previous dementia diagnosis or substantial memory complaints (<jats:italic>\u03b2<\/jats:italic>\u00a0=\u00a0\u22120.606, 95% CI =\u00a0\u22120.877;\u22120.335), frailty before hospitalization (<jats:italic>\u03b2<\/jats:italic>\u00a0=\u00a0\u22120.191, 95% CI =\u00a0\u22120.264;\u22120.119), higher platelet count (<jats:italic>\u03b2<\/jats:italic>\u00a0=\u00a0\u22120.101, 95% CI =\u00a0\u22120.185;\u22120.018), and delirium (<jats:italic>\u03b2<\/jats:italic>\u00a0=\u00a0\u22120.483, 95% CI =\u00a0\u22120.724;\u22120.244). Post\u2010discharge predictors included hospital readmissions and frailty.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Cognitive impairment was common and the patterns of cognitive trajectories depended on sociodemographic, in\u2010hospital, and post\u2010hospitalization predictors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Cognitive impairment after coronavirus disease 2019 (COVID\u201019) hospital discharge was associated with higher age, less education, delirium during hospitalization, a higher number of hospitalizations post discharge, and frailty before and after hospitalization.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Frequent cognitive evaluations for 12\u2010month post\u2010COVID\u201019 hospitalization showed three possible cognitive trajectories: no cognitive impairment, initial short\u2010term impairment, and long\u2010term impairment.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>This study highlights the importance of frequent cognitive testing to determine patterns of COVID\u201019 cognitive impairment, given the high frequency of incident cognitive impairment 1 year after hospitalization.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.12993","type":"journal-article","created":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T07:00:55Z","timestamp":1677740455000},"page":"3771-3782","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Dissipating the fog: Cognitive trajectories and risk factors 1 year after COVID\u201019 hospitalization"],"prefix":"10.1002","volume":"19","author":[{"given":"Natalia Gomes","family":"Gon\u00e7alves","sequence":"first","affiliation":[{"name":"Department of Pathology Faculdade de Medicina da Universidade de S\u00e3o Paulo FMUSP  S\u00e3o Paulo 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