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Based on <jats:italic>ante mortem<\/jats:italic> clinical diagnosis, participants were divided into non\u2010dementia and dementia, as early or late clinical stages.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Amyloid positron emission tomography (PET) and cerebrospinal fluid (CSF) amyloid beta (A\u03b2)42\/phosphorylated tau (p\u2010tau)181 showed excellent performance in differentiating autopsy\u2010confirmed AD and predicting the risk of neuropathological changes in early and late clinical stages. However, CSF A\u03b242 performed better in the early clinical stage, while CSF p\u2010tau181, CSF t\u2010tau, and plasma p\u2010tau181 performed better in the late clinical stage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Our findings provide important clinical information that, if using PET, CSF, and plasma biomarkers to detect AD pathology, researchers must consider their differential performances at different clinical stages of AD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Amyloid PET and CSF A\u03b242\/p\u2010tau181 were the most promising candidate biomarkers for predicting AD pathology.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>CSF A\u03b242 can serve as a candidate predictive biomarker in the early clinical stage of AD.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>CSF p\u2010tau181, CSF t\u2010tau, and plasma p\u2010tau181 can serve as candidate predictive biomarkers in the late clinical stage of AD.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Combining <jats:italic>APOE<\/jats:italic> \u03b54\u00a0genotypes\u00a0can significantly improve the predictive accuracy of AD\u2010related biomarkers for AD pathology.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.12997","type":"journal-article","created":{"date-parts":[[2023,2,25]],"date-time":"2023-02-25T07:44:01Z","timestamp":1677311041000},"page":"3613-3624","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Differences between <i>ante mortem<\/i> Alzheimer's disease biomarkers in predicting neuropathology at autopsy"],"prefix":"10.1002","volume":"19","author":[{"given":"Zhi\u2010Bo","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurology Qingdao Municipal Hospital Qingdao University  Qingdao 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