{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T19:39:02Z","timestamp":1792438742593,"version":"4.5.0"},"reference-count":51,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T00:00:00Z","timestamp":1680739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Basal forebrain (BF) degeneration occurs in Down syndrome (DS)\u2010associated Alzheimer's disease (AD). However, the dynamics of BF atrophy with age and disease progression, its impact on cognition, and its relationship with AD biomarkers have not been studied in DS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included 234 adults with DS (150 asymptomatic, 38 prodromal AD, and 46 AD dementia) and 147 euploid controls. BF volumes were extracted from T\u2010weighted\u00a0magnetic resonance images using a stereotactic atlas in SPM12. We assessed BF volume changes with age and along the clinical AD continuum and their relationship to cognitive performance, cerebrospinal fluid (CSF) and plasma amyloid\/tau\/neurodegeneration biomarkers, and hippocampal volume.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In DS, BF volumes decreased with age and along the clinical AD continuum and significantly correlated with amyloid, tau, and neurofilament light chain changes in CSF and plasma, hippocampal volume, and cognitive performance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>BF atrophy is a potentially valuable neuroimaging biomarker of AD\u2010related cholinergic neurodegeneration in DS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.12999","type":"journal-article","created":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T05:09:08Z","timestamp":1680757748000},"page":"4817-4827","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Basal forebrain atrophy along the Alzheimer's disease continuum in adults with Down syndrome"],"prefix":"10.1002","volume":"19","author":[{"given":"Mateus","family":"Rozalem Aranha","sequence":"first","affiliation":[{"name":"Sant Pau Memory Unit Department of Neurology Hospital de la Santa Creu i Sant Pau Institut d'Investigaci\u00f3 Biom\u00e8dica Sant Pau (IIB SANT PAU) Facultad de Medicina \u2010 Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"},{"name":"Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria 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