{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:48:56Z","timestamp":1790869736856,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,2,18]],"date-time":"2023-02-18T00:00:00Z","timestamp":1676678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["446002504"],"award-info":[{"award-number":["446002504"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>INTRODUCTION<\/jats:title><jats:p>Early health\u2010technology assessment can support discussing scarce resource allocation among stakeholders. We explored the value of maintaining cognition in patients with mild cognitive impairment (MCI) by estimating: (1) the innovation headroom and (2) the potential cost effectiveness of roflumilast treatment in this population.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>The innovation headroom was operationalized by a fictive 100% efficacious treatment effect, and the roflumilast effect on memory word learning test was assumed to be associated with 7% relative risk reduction of dementia onset. Both were compared to Dutch setting usual care using the adapted International Pharmaco\u2010Economic Collaboration on Alzheimer's Disease (IPECAD)\u00a0open\u2010source model.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The total innovation headroom expressed as net health benefit was 4.2 (95% bootstrap\u00a0interval: 2.9\u20135.7) quality\u2010adjusted life years (QALYs). The potential cost effectiveness of roflumilast was k\u20ac34 per QALY.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>The innovation headroom in MCI is substantial. Although the potential cost effectiveness of roflumilast treatment is uncertain, further research on its effect on dementia onset is likely valuable.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.13001","type":"journal-article","created":{"date-parts":[[2023,2,18]],"date-time":"2023-02-18T15:43:17Z","timestamp":1676734997000},"page":"3458-3471","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The value of maintaining cognition in patients with mild cognitive impairment: The innovation headroom and potential cost\u2010effectiveness of roflumilast"],"prefix":"10.1002","volume":"19","author":[{"given":"Ron","family":"Handels","sequence":"first","affiliation":[{"name":"Department of Psychiatry &amp; Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Centre Limburg Maastricht University  Maastricht the Netherlands"},{"name":"Division of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society Karolinska Institutet  Solna Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Grimm","sequence":"additional","affiliation":[{"name":"KEMTA Maastricht University Medical Center  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjan","family":"Blokland","sequence":"additional","affiliation":[{"name":"Department of Neuropsychology and Psychopharmacology, EURON, Faculty of Psychology and Neuroscience Maastricht University  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Possemis","sequence":"additional","affiliation":[{"name":"Department of Psychiatry &amp; Neuropsychology, School for Mental Health and Neuroscience, EURON Maastricht University  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inez","family":"Ramakers","sequence":"additional","affiliation":[{"name":"Department of Psychiatry &amp; Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Centre Limburg Maastricht University  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke","family":"Sambeth","sequence":"additional","affiliation":[{"name":"Department of Neuropsychology and Psychopharmacology, EURON, Faculty of Psychology and Neuroscience Maastricht University  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frans","family":"Verhey","sequence":"additional","affiliation":[{"name":"Department of Psychiatry &amp; Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Centre Limburg Maastricht University  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Vos","sequence":"additional","affiliation":[{"name":"Department of Psychiatry &amp; Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Centre Limburg Maastricht University  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Joore","sequence":"additional","affiliation":[{"name":"KEMTA Maastricht University Medical Center  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos","family":"Prickaerts","sequence":"additional","affiliation":[{"name":"Department of Psychiatry &amp; Neuropsychology, School for Mental Health and Neuroscience, EURON Maastricht University  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linus","family":"J\u00f6nsson","sequence":"additional","affiliation":[{"name":"Division of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society Karolinska Institutet  Solna Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468\u20102667(21)00249\u20108"},{"key":"e_1_2_10_3_1","volume-title":"2021. 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