{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T15:04:45Z","timestamp":1791990285801,"version":"4.4.0"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,3,18]],"date-time":"2023-03-18T00:00:00Z","timestamp":1679097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>In Alzheimer's disease (AD), hyperphosphorylated tau is closely associated with focal neurodegeneration, but the mechanism remains uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We quantified cortical microstructure using neurite orientation dispersion and density imaging in 14 individuals with young onset AD. Diffusion tensor imaging measured mean diffusivity (MD). Amyloid beta and tau positron emission tomography were acquired and associations with microstructural measures were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      When regional volume was adjusted for, in the medial temporal lobe there was a significant negative association between neurite density and tau (partial R\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a00.56,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.008) and between orientation dispersion and tau (partial R\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a00.66,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.002), but not between MD and tau. In a wider cortical composite, there was an association between orientation dispersion and tau (partial R\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a00.43,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.030), but not between other measures and tau.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Our findings are consistent with tau causing first dendritic pruning (reducing dispersion\/complexity) followed by neuronal loss. Advanced magnetic resonance imaging (MRI) microstructural measures have the potential to provide information relating to underlying tau deposition.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.13011","type":"journal-article","created":{"date-parts":[[2023,3,18]],"date-time":"2023-03-18T10:09:25Z","timestamp":1679134165000},"page":"2750-2754","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Cortical tau is associated with microstructural imaging biomarkers of neurite density and dendritic complexity in Alzheimer's disease"],"prefix":"10.1002","volume":"19","author":[{"given":"Philip S. J.","family":"Weston","sequence":"first","affiliation":[{"name":"The Dementia Research Centre, Department of Neurodegenerative Disease UCL Queen Square Institute of Neurology  London UK"},{"name":"UK Dementia Research Institute at UCL University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Coath","sequence":"additional","affiliation":[{"name":"The Dementia Research Centre, Department of Neurodegenerative Disease UCL Queen Square Institute of Neurology  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Harris","sequence":"additional","affiliation":[{"name":"The Dementia Research Centre, Department of Neurodegenerative Disease UCL Queen Square Institute of Neurology  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian B.","family":"Malone","sequence":"additional","affiliation":[{"name":"The Dementia Research Centre, Department of Neurodegenerative Disease UCL Queen Square Institute of Neurology  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Dickson","sequence":"additional","affiliation":[{"name":"Institute of Nuclear Medicine University College London Hospitals  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franklin I.","family":"Aigbirhio","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences University of Cambridge  Cambridge UK"},{"name":"Wolfson Brain Imaging Centre University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Cash","sequence":"additional","affiliation":[{"name":"The Dementia Research Centre, Department of Neurodegenerative Disease UCL Queen Square Institute of Neurology  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Computer Science and Centre for Medical Image Computing University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan M.","family":"Schott","sequence":"additional","affiliation":[{"name":"The Dementia Research Centre, Department of Neurodegenerative Disease UCL Queen Square Institute of Neurology  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-7091-6467-9_11"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww027"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt088"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.08.042"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2017.09.013"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-020-00679-2"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-015-0132-3"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.03.072"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22872"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/2058460117703816"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70090-0"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000351671"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-017-0846-x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30228-5"},{"key":"e_1_2_8_16_1","first-page":"262","article-title":"Geodesic information flows","volume":"15","author":"Cardoso MJ","year":"2012","journal-title":"Med Image Comput Comput Assist Interv"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JMI.1.2.024003"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2021.118749"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23650"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410410106"},{"key":"e_1_2_8_21_1","first-page":"22","article-title":"Machine learning and novel biomarkers for the diagnosis of Alzheimer's disease","author":"Chang CH","year":"2021","journal-title":"Int J Mol Sci"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2020.117560"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12364"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.10.043"}],"container-title":["Alzheimer's &amp; 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