{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:03:40Z","timestamp":1790697820851,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T00:00:00Z","timestamp":1678838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>INTRODUCTION<\/jats:title><jats:p>Amyloid\u2010\u03b2 (A\u03b2) and tau can be quantified in blood. However, biological factors can influence the levels of brain\u2010derived proteins in the blood. The blood\u2010brain barrier (BBB) regulates protein transport between cerebrospinal fluid (CSF) and blood. BBB altered permeability might affect the relationship between brain and blood biomarkers.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>We assessed 224 participants in research (TRIAD, <jats:italic>n<\/jats:italic>\u00a0=\u00a096) and clinical (BIODEGMAR, <jats:italic>n<\/jats:italic>\u00a0=\u00a0128) cohorts with plasma and CSF\/positron emission tomography A\u03b2, p\u2010tau, and albumin measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Plasma A\u03b2<jats:sub>42\/40<\/jats:sub> better identified CSF A\u03b2<jats:sub>42\/40<\/jats:sub> and A\u03b2\u2010PET positivity in individuals with high BBB permeability. An interaction between plasma A\u03b2<jats:sub>42\/40<\/jats:sub> and BBB permeability on CSF A\u03b2<jats:sub>42\/40<\/jats:sub> was observed. Voxel\u2010wise models estimated that the association of positron emission tomography (PET), with plasma A\u03b2 was most affected by BBB permeability in AD\u2010related brain regions. BBB permeability did not significantly impact the relationship between brain and plasma p\u2010tau levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>These findings suggest that BBB integrity may influence the performance of plasma A\u03b2, but not p\u2010tau, biomarkers in research and clinical settings.<\/jats:p><\/jats:sec><jats:sec><jats:title>HIGHLIGHTS<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>BBB permeability affects the association between brain and plasma A\u03b2 levels.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>BBB integrity does not affect the association between brain and plasma p\u2010tau levels.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Plasma A\u03b2 was most affected by BBB permeability in AD\u2010related brain regions.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>BBB permeability increases with age but not according to cognitive status.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.13014","type":"journal-article","created":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T04:49:15Z","timestamp":1678855755000},"page":"3815-3825","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Blood\u2010brain barrier integrity impacts the use of plasma amyloid\u2010\u03b2 as a proxy of brain amyloid\u2010\u03b2 pathology"],"prefix":"10.1002","volume":"19","author":[{"given":"Bruna","family":"Bellaver","sequence":"first","affiliation":[{"name":"Department of Psychiatry University of Pittsburgh  Pittsburgh Pennsylvania USA"},{"name":"Graduate Program in Biological Sciences: Biochemistry Universidade Federal do Rio Grande do Sul  Porto Alegre Rio Grande do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Puig\u2010Pijoan","sequence":"additional","affiliation":[{"name":"Cognitive Decline and Movement Disorders Unit, Neurology Department Hospital del Mar  Barcelona Spain"},{"name":"IMIM (Hospital del Mar Medical Research Institute)  Barcelona Spain"},{"name":"Department of Medicine Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Pedro","family":"Ferrari\u2010Souza","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Pittsburgh  Pittsburgh Pennsylvania USA"},{"name":"Graduate Program in Biological Sciences: Biochemistry Universidade Federal do Rio Grande do Sul  Porto Alegre Rio Grande do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas T.","family":"Leffa","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Firoza Z.","family":"Lussier","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela C. 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