{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T22:11:56Z","timestamp":1791670316705,"version":"4.3.4"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T00:00:00Z","timestamp":1678924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Despite the substantial accuracy of plasma p\u2010tau in diagnosing Alzheimer's disease (AD) in research cohorts, data on real\u2010life memory clinic patients are lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Memory clinic patients at their early symptomatic stages were prospectively enrolled to undergo routine clinical assessment, plasma p\u2010tau181 quantification (Simoa), amyloid and tau\u2010positron emission tomography (PET). The diagnostic performance of plasma p\u2010tau181, neurocognitive specialists, and regional tau\u2010PET were compared head\u2010to\u2010head using amyloid\u2010PET as the reference standard.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Plasma p\u2010tau181 has the area under the curve (AUC), sensitivity, specificity, and accuracy of 0.84 (95% confidence interval [CI] 0.73\u20130.94), 0.80 (95% CI 0.64\u20130.90), 0.75 (95% CI 0.51\u20130.90), and 0.78 (95% CI 0.65\u20130.88) for detecting amyloid\u2010PET positivity in early symptomatic patients, respectively. The AUC of clinical diagnosis and tau\u2010PET were 0.70 (95% CI 0.56\u20130.85) and 0.88 (95% CI 0.79\u20130.97), respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Plasma p\u2010tau181 also performed well in real\u2010life memory clinic settings and its role in clinical practice is supported.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.13022","type":"journal-article","created":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T07:02:45Z","timestamp":1678950165000},"page":"2745-2749","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Prospective evaluation of plasma phosphorylated tau in a real\u2010life memory clinic in Thailand"],"prefix":"10.1002","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1317-9404","authenticated-orcid":false,"given":"Poosanu","family":"Thanapornsangsuth","sequence":"first","affiliation":[{"name":"Thai Red Cross Emerging Infectious Diseases Health Science Centre World Health Organization Collaborating Centre for Research and Training on Viral Zoonoses King Chulalongkorn Memorial Hospital The Thai Red Cross Society  Bangkok Thailand"},{"name":"Division of Neurology Department of Medicine Faculty of Medicine Chulalongkorn University  Bangkok Thailand"},{"name":"Memory Clinic King Chulalongkorn Memorial Hospital The Thai Red Cross Society  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kittithatch","family":"Booncharoen","sequence":"additional","affiliation":[{"name":"Division of Neurology Department of Medicine Faculty of Medicine Chulalongkorn University  Bangkok Thailand"},{"name":"Memory Clinic King Chulalongkorn Memorial Hospital The Thai Red Cross Society  Bangkok Thailand"},{"name":"Neurocognitive Unit Division of Neurology Department of Medicine Faculty of Medicine Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Watayuth","family":"Luechaipanit","sequence":"additional","affiliation":[{"name":"Thai Red Cross Emerging Infectious Diseases Health Science Centre World Health Organization Collaborating Centre for Research and Training on Viral Zoonoses King Chulalongkorn Memorial Hospital The Thai Red Cross Society  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thirawat","family":"Supharatpariyakorn","sequence":"additional","affiliation":[{"name":"Thai Red Cross Emerging Infectious Diseases Health Science Centre World Health Organization Collaborating Centre for Research and Training on Viral Zoonoses King Chulalongkorn Memorial Hospital The Thai Red Cross Society  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuthachai","family":"Sarutikriangkri","sequence":"additional","affiliation":[{"name":"Memory Clinic King Chulalongkorn Memorial Hospital The Thai Red Cross Society  Bangkok Thailand"},{"name":"Neurocognitive Unit Division of Neurology Department of Medicine Faculty of Medicine Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suchart","family":"Tangnimitchok","sequence":"additional","affiliation":[{"name":"Chulalongkorn Comprehensive Epilepsy Center of Excellence King Chulalongkorn Memorial Hospital The Thai Red Cross Society  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuttachai","family":"Likitjaroen","sequence":"additional","affiliation":[{"name":"Division of Neurology Department of Medicine Faculty of Medicine Chulalongkorn University  Bangkok Thailand"},{"name":"Memory Clinic King Chulalongkorn Memorial Hospital The Thai Red Cross Society  Bangkok Thailand"},{"name":"Neurocognitive Unit Division of Neurology Department of Medicine Faculty of Medicine Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chanan","family":"Sukprakun","sequence":"additional","affiliation":[{"name":"Division of Nuclear Medicine Department of Radiology Faculty of Medicine Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Supatporn","family":"Tepmongkol","sequence":"additional","affiliation":[{"name":"Division of Nuclear Medicine Department of Radiology Faculty of Medicine Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiravat","family":"Hemachudha","sequence":"additional","affiliation":[{"name":"Thai Red Cross Emerging Infectious Diseases Health Science Centre World Health Organization Collaborating Centre for Research and Training on Viral 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