{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:23:44Z","timestamp":1790115824312,"version":"4.0.1"},"reference-count":41,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T00:00:00Z","timestamp":1679270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The objective was to analyze associations between dietary intake of multiple nutrients and altered cognitive function and\/or decline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Observational analyses of participants (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a06334) in two randomized trials of nutritional supplements for age\u2010related macular degeneration: Age\u2010Related Eye Disease Study (AREDS) and AREDS2.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In AREDS, for 4 of 38 nutrients examined, higher intake quintiles were significantly associated with decreased risk of cognitive impairment on the Modified Mini\u2010Mental State test (&lt;80): \u03b2\u2010carotene, copper, docosahexaenoic acid, and insoluble fiber. In AREDS2, for 13 of 44 nutrients, higher intake quintiles were associated with decreased risk on the Telephone Interview Cognitive Status\u2010Modified (&lt;30). Rate of cognitive decline over up to 10 years was not significantly different with higher intake of any nutrient.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Higher dietary intake of multiple nutrients, including specific vitamins, minerals, carotenoids, fatty acids, and fiber, was associated with lower risk of cognitive impairment but not slower decline in cognitive function.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.13033","type":"journal-article","created":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T07:24:35Z","timestamp":1679297075000},"page":"4311-4324","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Dietary nutrient intake and cognitive function in the Age\u2010Related Eye Disease Studies 1 and 2"],"prefix":"10.1002","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2253-1772","authenticated-orcid":false,"given":"Tiarnan D. L.","family":"Keenan","sequence":"first","affiliation":[{"name":"Division of Epidemiology and Clinical Applications National Eye Institute National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvira","family":"Agr\u00f3n","sequence":"additional","affiliation":[{"name":"Division of Epidemiology and Clinical Applications National Eye Institute National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily Y.","family":"Chew","sequence":"additional","affiliation":[{"name":"Division of Epidemiology and Clinical Applications National Eye Institute National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the AREDS and AREDS2 Research Groups","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40266-015-0266-9"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.7326\/M17-1529"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70136-X"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-161201"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21326"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2016.00022"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00004.2002"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2004.08.001"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa025039"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.311.7018.1457"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dadm.2017.01.005"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-017-1763-2"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0000000000000795"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-179940"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114518002945"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13113728"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-2456(99)00031-8"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.05.027"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12077"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.124.4.537"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.9677"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/09286580591003815"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.125.5.671"},{"issue":"4","key":"e_1_2_7_25_1","first-page":"283","article-title":"Associations of plasma carotenoid concentrations and dietary intake of specific carotenoids in samples of two prospective cohort studies using a new carotenoid database","volume":"7","author":"Michaud DS","year":"1998","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a116211"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3448"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes10030222"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1368980013001390"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/65.4.1220S"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1007529206050"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu7115459"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-180549"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2009.75"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu4122097"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.16909"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-200926"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqaa373"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12172"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2020.08.018"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwg091"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwg092"}],"container-title":["Alzheimer's &amp; 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