{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T07:15:35Z","timestamp":1775978135336,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T00:00:00Z","timestamp":1679443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["#2017\u201000915"],"award-info":[{"award-number":["#2017\u201000915"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008599","name":"Alzheimerfonden","doi-asserted-by":"publisher","award":["AF\u2010930934"],"award-info":[{"award-number":["AF\u2010930934"]}],"id":[{"id":"10.13039\/501100008599","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>INTRODUCTION<\/jats:title><jats:p>Secernin\u20101 (SCRN1) is a neuronal protein that co\u2010localizes with neurofibrillary tangles in Alzheimer's disease (AD), but not with tau inclusions in corticobasal degeneration (CBD), progressive supranuclear palsy (PSP), or Pick's disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>We measured SCRN1 concentration in cerebrospinal fluid (CSF) using a novel mass spectrometric parallel reaction monitoring method in three clinical cohorts comprising patients with neurochemically characterized AD (<jats:italic>n<\/jats:italic>\u00a0=\u00a025) and controls (<jats:italic>n<\/jats:italic>\u00a0=\u00a028), clinically diagnosed Parkinson's disease (PD; <jats:italic>n<\/jats:italic>\u00a0=\u00a038), multiple system atrophy (MSA; <jats:italic>n<\/jats:italic>\u00a0=\u00a031), PSP (<jats:italic>n<\/jats:italic>\u00a0=\u00a020), CBD (<jats:italic>n<\/jats:italic>\u00a0=\u00a08), healthy controls (<jats:italic>n<\/jats:italic>\u00a0=\u00a037), and neuropathology\u2010confirmed AD (<jats:italic>n<\/jats:italic>\u00a0=\u00a047).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>CSF SCRN1 was significantly increased in AD (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01, fold change\u00a0=\u00a01.4) compared to controls (receiver operating characteristic area under the curve\u00a0=\u00a00.78) but not in CBD, PSP, PD, or MSA. CSF SCRN1 positively correlated with CSF total tau (<jats:italic>R<\/jats:italic>\u00a0=\u00a00.78, <jats:italic>P<\/jats:italic>\u00a0=\u00a01.1\u00a0\u00d7\u00a010<jats:sup>\u221213<\/jats:sup>), phosphorylated tau<jats:sub>181<\/jats:sub> (<jats:italic>R<\/jats:italic>\u00a0=\u00a00.64, <jats:italic>P<\/jats:italic>\u00a0=\u00a03.2\u00a0\u00d7\u00a010<jats:sup>\u22128<\/jats:sup>), and Braak stage and negatively correlated with Mini\u2010Mental State Examination score.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>CSF SCRN1 is a candidate biomarker of AD, reflecting tau pathology.<\/jats:p><\/jats:sec><jats:sec><jats:title>HIGHLIGHTS<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>We developed a parallel reaction monitoring assay to measure secernin\u20101 (SCRN1) in cerebrospinal fluid (CSF).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>CSF SCRN1 was increased in Alzheimer's disease compared to healthy controls.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>CSF SCRN1 remained unchanged in Parkinson's disease, multiple system atrophy, progressive supranuclear palsy, or corticobasal degeneration compared to controls.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>CSF SCRN1 correlated strongly with CSF phosphorylated tau and total tau.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>CSF SCRN1 increased across Braak stages and negatively correlated with Mini\u2010Mental State Examination score.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.13042","type":"journal-article","created":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T09:09:42Z","timestamp":1679476182000},"page":"4609-4618","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["SCRN1: A cerebrospinal fluid biomarker correlating with tau in Alzheimer's disease"],"prefix":"10.1002","volume":"19","author":[{"given":"Sophia","family":"Weiner","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology University of Gothenburg  M\u00f6lndal Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathias","family":"Sauer","sequence":"additional","affiliation":[{"name":"Clinical Neurochemistry Laboratory Institute of Neuroscience and Physiology Sahlgrenska University Hospital  M\u00f6lndal Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunnar","family":"Brinkmalm","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology University of Gothenburg  M\u00f6lndal Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julius","family":"Constantinescu","sequence":"additional","affiliation":[{"name":"Department of Neurology Institute of Neuroscience and Physiology The Sahlgrenska Academy at the University of Gothenburg  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radu","family":"Constantinescu","sequence":"additional","affiliation":[{"name":"Department of Neurology Institute of Neuroscience and Physiology The Sahlgrenska Academy at the University of Gothenburg  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e1rbara Fernandes","family":"Gomes","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology University of Gothenburg  M\u00f6lndal Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Becker","sequence":"additional","affiliation":[{"name":"Clinical Neurochemistry Laboratory Institute of Neuroscience and Physiology Sahlgrenska University Hospital  M\u00f6lndal Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bengt","family":"Nellg\u00e5rd","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine Institute of Clinical Sciences Sahlgrenska University Hospital  M\u00f6lndal Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keti","family":"Dalla","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine Institute of Clinical Sciences Sahlgrenska University Hospital  M\u00f6lndal Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas","family":"Galasko","sequence":"additional","affiliation":[{"name":"Department of Neurosciences University of California, San Diego  La Jolla California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry Institute of 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