{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T23:58:24Z","timestamp":1790639904173,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T00:00:00Z","timestamp":1680048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>A combination of plasma phospho\u2010tau (p\u2010tau), amyloid beta (A\u03b2)\u2010positron emission tomography (PET), brain magnetic resonance imaging, cognitive function tests, and other biomarkers might predict future cognitive decline. This study aimed to investigate the efficacy of combining these biomarkers in predicting future cognitive stage transitions within 3 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Among the participants in the Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's Disease (KBASE\u2010V) study, 49 mild cognitive impairment (MCI) and 113 cognitively unimpaired (CU) participants with A\u03b2\u2010PET and brain imaging data were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Older age, increased plasma p\u2010tau181, A\u03b2\u2010PET positivity, and decreased semantic fluency were independently associated with cognitive stage transitions. Combining age, p\u2010tau181, the Centiloid scale, semantic fluency, and hippocampal volume produced high predictive value in predicting future cognitive stage transition (area under the curve\u00a0=\u00a00.879).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Plasma p\u2010tau181 and Centiloid scale alone or in combination with other biomarkers, might predict future cognitive stage transition in non\u2010dementia patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>Plasma p\u2010tau181 and Centiloid scale might predict future cognitive stage transition.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Combining them or adding other biomarkers increased the predictive value.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Factors that independently associated with cognitive stage transition were demonstrated.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.13054","type":"journal-article","created":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T09:27:37Z","timestamp":1680082057000},"page":"4641-4650","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Predicting cognitive stage transition using p\u2010tau181, Centiloid, and other measures"],"prefix":"10.1002","volume":"19","author":[{"given":"Hyuk Sung","family":"Kwon","sequence":"first","affiliation":[{"name":"Department of Neurology Hanyang University Guri Hospital Hanyang University College of Medicine  Guri Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Hanyang University Guri Hospital Hanyang University College of Medicine  Guri Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5419-5761","authenticated-orcid":false,"given":"Seong\u2010Ho","family":"Koh","sequence":"additional","affiliation":[{"name":"Department of Neurology Hanyang University Guri Hospital Hanyang University College of Medicine  Guri Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Hye","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Neurology Inha University College of Medicine  Incheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun\u2010Hye","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology Hanyang University Guri Hospital Hanyang University College of Medicine  Guri Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jee Hyang","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Neurology Ewha Womans University School of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae\u2010Won","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Neurology Kangwon National University School of Medicine  Chuncheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Won","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Neurology Dong\u2010A Medical Center Dong\u2010A University College of Medicine  Busan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun\u2010Joo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology Pusan National University Hospital Pusan National University School of Medicine and Medical Research Institute  Busan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Yong","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Neurology Yonsei University Wonju College of Medicine  Wonju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo Jin","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Neurology Eulji University Hospital Eulji University School of Medicine  Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bora","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Neurology Konyang University College of Medicine  Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun\u2010Hee","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Neurology Hanyang University Guri Hospital Hanyang University College of Medicine  Guri Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myung Hoon","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Hanyang University Guri Hospital Hanyang University College of Medicine  Guri Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01348-z"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2022.30"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-021-00953-x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2018.0894"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.274"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2021-327370"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3988\/jcn.2022.18.4.401"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-0755-1"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2013.11.005"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.07.003"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-020-04942-4"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8030341"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617704101094"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002093-200304000-00008"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3988\/jcn.2019.15.3.292"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.008"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.58.12.1985"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.12779\/dnd.2018.17.1.11"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2004.01.004"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.114.512.797"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.102893"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2015.05.004"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2002.806283"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1109\/42.668698"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-199403000-00005"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.10062"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.03.036"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2000.0652"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.02.046"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.018"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11307-021-01660-7"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-020-00587-5"},{"key":"e_1_2_10_34_1","volume-title":"Diagnostic and statistical manual of mental disorders: DSM\u2010IV\u2010TR","author":"Association AP","year":"2000"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1177\/0049124104268644"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.2-71.v1"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12395"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-019-0478-z"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201606210"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.13054","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T15:47:29Z","timestamp":1759938449000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.13054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,29]]},"references-count":39,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1002\/alz.13054"],"URL":"https:\/\/doi.org\/10.1002\/alz.13054","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,29]]},"assertion":[{"value":"2022-12-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}