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While anterior\/posterior CA show co\u2010metabolism with different regions of the subcortical limbic networks, the anterior\/posterior subiculum are parts of cortical networks supporting object\u2010centered memory and higher cognitive demands, respectively. Both networks show relationships with the spatial patterns of gene expression pertaining to cell energy metabolism and AD's process. Finally, while local metabolism is generally lower in posterior regions, the anterior\u2013posterior imbalance is maximal in late mild cognitive impairment with the anterior subiculum being relatively preserved.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Future studies should consider bidimensional hippocampal differentiation and in particular the posterior subicular region to better understand pathological aging.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.13056","type":"journal-article","created":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T14:10:03Z","timestamp":1680617403000},"page":"4787-4804","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Hippocampal metabolic subregions and networks: Behavioral, molecular, and pathological aging 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