{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T22:15:32Z","timestamp":1787782532679,"version":"build-2784847793"},"reference-count":67,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,4,18]],"date-time":"2023-04-18T00:00:00Z","timestamp":1681776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82020108013"],"award-info":[{"award-number":["82020108013"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010007","name":"Chinesisch-Deutsche Zentrum f\u00fcr Wissenschaftsf\u00f6rderung","doi-asserted-by":"publisher","award":["GZ1370"],"award-info":[{"award-number":["GZ1370"]}],"id":[{"id":"10.13039\/501100010007","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010007","name":"Chinesisch-Deutsche Zentrum f\u00fcr Wissenschaftsf\u00f6rderung","doi-asserted-by":"publisher","award":["GZ1425"],"award-info":[{"award-number":["GZ1425"]}],"id":[{"id":"10.13039\/501100010007","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010007","name":"Chinesisch-Deutsche Zentrum f\u00fcr Wissenschaftsf\u00f6rderung","doi-asserted-by":"publisher","award":["GZ1567"],"award-info":[{"award-number":["GZ1567"]}],"id":[{"id":"10.13039\/501100010007","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010007","name":"Chinesisch-Deutsche Zentrum f\u00fcr Wissenschaftsf\u00f6rderung","doi-asserted-by":"publisher","award":["M\u20100759"],"award-info":[{"award-number":["M\u20100759"]}],"id":[{"id":"10.13039\/501100010007","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005224","name":"Deutsches Zentrum f\u00fcr Neurodegenerative Erkrankungen","doi-asserted-by":"publisher","award":["BN012"],"award-info":[{"award-number":["BN012"]}],"id":[{"id":"10.13039\/501100005224","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2023,11]]},"abstract":"Abstract<\/jats:title>\n \n INTRODUCTION<\/jats:title>\n It remains unclear whether functional brain networks are consistently altered in individuals with subjective cognitive decline (SCD) of diverse ethnic and cultural backgrounds and whether the network alterations are associated with an amyloid burden.<\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n Cross\u2010sectional resting\u2010state functional magnetic resonance imaging connectivity (FC) and amyloid\u2010positron emission tomography (PET) data from the Chinese Sino Longitudinal Study on Cognitive Decline and German DZNE Longitudinal Cognitive Impairment and Dementia cohorts were analyzed.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n Limbic FC, particularly hippocampal connectivity with right insula, was consistently higher in SCD than in controls, and correlated with SCD\u2010plus features. Smaller SCD subcohorts with PET showed inconsistent amyloid positivity rates and FC\u2013amyloid associations across cohorts.<\/jats:p>\n <\/jats:sec>\n \n DISCUSSION<\/jats:title>\n Our results suggest an early adaptation of the limbic network in SCD, which may reflect increased awareness of cognitive decline, irrespective of amyloid pathology. Different amyloid positivity rates may indicate a heterogeneous underlying etiology in Eastern and Western SCD cohorts when applying current research criteria. Future studies should identify culture\u2010specific features to enrich preclinical Alzheimer's disease in non\u2010Western populations.<\/jats:p>\n <\/jats:sec>\n \n Highlights<\/jats:title>\n \n \n \n Common limbic hyperconnectivity across Chinese and German subjective cognitive decline (SCD) cohorts was observed.<\/jats:p>\n <\/jats:list-item>\n \n Limbic hyperconnectivity may reflect awareness of cognition, irrespective of amyloid load.<\/jats:p>\n <\/jats:list-item>\n \n Further cross\u2010cultural harmonization of SCD regarding Alzheimer's disease pathology is required.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/alz.13068","type":"journal-article","created":{"date-parts":[[2023,4,18]],"date-time":"2023-04-18T07:56:17Z","timestamp":1681804577000},"page":"4922-4934","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Altered limbic functional connectivity in individuals with subjective cognitive decline: Converging and diverging findings across Chinese and German cohorts"],"prefix":"10.1002","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5231-2677","authenticated-orcid":false,"given":"Xueyan","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Neurology Xuanwu Hospital of Capital Medical University Beijing China"},{"name":"German Center for Neurodegenerative\u00a0Diseases (DZNE) Bonn Germany"},{"name":"Key Laboratory of Biomedical Engineering of Hainan Province School of Biomedical Engineering Hainan University Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4126-673X","authenticated-orcid":false,"given":"Xiaochen","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Cologne Medical Faculty Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3017-3901","authenticated-orcid":false,"given":"Marcel","family":"Daamen","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative\u00a0Diseases (DZNE) Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology Xuanwu Hospital of Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunqiu","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Neurology Xuanwu Hospital of Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dix","family":"Meiberth","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative\u00a0Diseases (DZNE) Bonn Germany"},{"name":"Department of Psychiatry, University of 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