{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T17:20:22Z","timestamp":1789320022611,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T00:00:00Z","timestamp":1681171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Down syndrome (DS) is a genetic form of Alzheimer's disease (AD). However, clinical diagnosis is difficult, and experts emphasize the need for detecting\u00a0intra\u2010individual cognitive decline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the performance of baseline and longitudinal neuropsychological assessments for the diagnosis of symptomatic AD in DS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Longitudinal cohort study of adults with DS. Individuals were classified as asymptomatic, prodromal AD, or AD dementia. We performed receiver operating characteristic curve analyses to compare baseline and longitudinal changes of CAMCOG\u2010DS and mCRT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 562 adults with DS. Baseline assessments showed good to excellent diagnostic performance for AD dementia (AUCs between\u00a00.82 and 0.99) and prodromal AD, higher than the 1\u2010year intra\u2010individual cognitive decline (area under the ROC curve between\u00a00.59 and 0.79\u00a0for AD dementia, lower for prodromal AD). Longer follow\u2010ups increased the diagnostic performance of the intra\u2010individual cognitive decline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Baseline cognitive assessment outperforms the 1\u2010year intra\u2010individual cognitive decline in adults with DS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.13073","type":"journal-article","created":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T03:00:27Z","timestamp":1681182027000},"page":"3916-3925","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Cross\u2010sectional versus longitudinal cognitive assessments for the diagnosis of symptomatic Alzheimer's disease in adults with Down syndrome"],"prefix":"10.1002","volume":"19","author":[{"given":"Laura","family":"Videla","sequence":"first","affiliation":[{"name":"Sant Pau Memory Unit Department of Neurology Institut d'Investigacions Biom\u00e8diques Sant Pau Hospital de Sant Pau 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