{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T13:00:29Z","timestamp":1772888429760,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,4,23]],"date-time":"2023-04-23T00:00:00Z","timestamp":1682208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>The Dominantly Inherited Alzheimer Network (DIAN) is a longitudinal observational study that collects data on cognition, blood pressure (BP), and other variables from autosomal\u2010dominant Alzheimer's disease mutation carriers (MCs) and non\u2010carrier (NC) family members in early to mid\u2010adulthood, providing a unique opportunity to evaluate\u00a0BP and cognition relationships in these populations.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHOD<\/jats:title><jats:p>We examined cross\u2010sectional and longitudinal relationships between systolic and diastolic BP and cognition in DIAN MC and NC.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Data were available from 528 participants, who had a\u00a0mean age of 38 (SD\u00a0=\u00a011) and were 42% male and 61% MCs, at a median follow\u2010up of 2 years. Linear\u2010multilevel models found only cross\u2010sectional associations in the MC group between higher systolic BP and poorer performance on language (\u03b2\u00a0=\u00a0\u22120.181 [\u22120.318, \u22120.044]), episodic memory (\u22120.212 [\u22120.375, \u22120.049]), and a composite cognitive measure (\u22120.146 [\u22120.276, \u22120.015]). In NCs, the relationship was cross\u2010sectional only and present for language alone.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>Higher systolic BP was cross\u2010sectionally but not longitudinally associated with poorer cognition, particularly in MCs. BP may influence cognition gradually, but further longitudinal research is needed.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.13082","type":"journal-article","created":{"date-parts":[[2023,4,23]],"date-time":"2023-04-23T10:16:40Z","timestamp":1682245000000},"page":"4999-5009","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Higher systolic blood pressure in early\u2010mid adulthood is associated with poorer cognitive performance in those with a dominantly inherited Alzheimer's disease mutation but not in non\u2010carriers. 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