{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:42:15Z","timestamp":1790296935630,"version":"4.1.0"},"reference-count":70,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T00:00:00Z","timestamp":1682294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Neuropathological substrates associated with neurodegeneration occur in brains of the oldest old. How does this affect cognitive performance?<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      The 100\u2010plus Study is an ongoing longitudinal cohort study of centenarians who self\u2010report to be cognitively healthy;\n                      <jats:italic>post mortem<\/jats:italic>\n                      brain donation is optional. In 85 centenarian brains, we explored the correlations between the levels of 11 neuropathological substrates with\n                      <jats:italic>ante mortem<\/jats:italic>\n                      performance on 12 neuropsychological tests.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Levels of neuropathological substrates varied: we observed levels up to Thal\u2010amyloid beta phase 5, Braak\u2010neurofibrillary tangle (NFT) stage V, Consortium to Establish a Registry for Alzheimer's Disease (CERAD)\u2010neuritic plaque score 3, Thal\u2010cerebral amyloid angiopathy stage 3, Tar\u2010DNA binding protein 43 (TDP\u201043) stage 3, hippocampal sclerosis stage 1, Braak\u2010Lewy bodies stage 6, atherosclerosis stage 3, cerebral infarcts stage 1, and cerebral atrophy stage 2. Granulovacuolar degeneration occurred in all centenarians. Some high performers had the highest neuropathology scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Only Braak\u2010NFT stage and limbic\u2010predominant age\u2010related TDP\u201043 encephalopathy (LATE) pathology associated significantly with performance across multiple cognitive domains. Of all cognitive tests, the clock\u2010drawing test was particularly sensitive to levels of multiple neuropathologies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.13087","type":"journal-article","created":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T04:55:11Z","timestamp":1682312111000},"page":"5036-5047","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["The correlation between neuropathology levels and cognitive performance in centenarians"],"prefix":"10.1002","volume":"19","author":[{"given":"Meng","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Human Genetics, Genomics of Neurodegenerative Diseases and Aging, Neuroscience Vrije Universiteit Amsterdam  Amsterdam The Netherlands"},{"name":"Delft Bioinformatics Lab Delft Technical University  Van The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea B.","family":"Ganz","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, Genomics of Neurodegenerative Diseases and Aging, Neuroscience Vrije Universiteit Amsterdam  Amsterdam The Netherlands"},{"name":"Department of Neurology, Alzheimer Center Amsterdam, Neuroscience Vrije Universiteit Amsterdam  Amsterdam The Netherlands"},{"name":"Department of Molecular and Cellular Neuroscience, Center for Neurogenomics and Cognitive Research, Neuroscience Vrije Universiteit Amsterdam  Amsterdam The Netherlands"},{"name":"Department of Pathology Neuroscience  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Rohde","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, Genomics of Neurodegenerative Diseases and Aging, Neuroscience Vrije Universiteit Amsterdam  Amsterdam The Netherlands"},{"name":"Department of Neurology, Alzheimer Center Amsterdam, Neuroscience Vrije Universiteit Amsterdam  Amsterdam The Netherlands"},{"name":"Department of Pathology Neuroscience  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Lorenz","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, Genomics of Neurodegenerative Diseases and Aging, Neuroscience Vrije Universiteit Amsterdam  Amsterdam The Netherlands"},{"name":"Department of Neurology, Alzheimer Center Amsterdam, Neuroscience Vrije Universiteit Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemieke J. 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