{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:31:43Z","timestamp":1790652703966,"version":"4.1.0"},"reference-count":10,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T00:00:00Z","timestamp":1682553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The study recently published on the clinical effect of lecanemab in early Alzheimer's disease (AD) only includes patients with amnestic presentation. However, a significant portion of AD patients presents a non\u2010amnestic phenotype of AD, such as primary progressive aphasia (PPA) and could benefit of rather than on lecanemab. Therefore, we conducted a 10\u2010year retrospective study at the Leenaards Memory Center in Lausanne (Switzerland) to identify how many PPA patients would be eligible for lecanemab. Among 54 patients with PPA, we identified 11 (20%) eligible patients. Furthermore, almost half of the 18 patients with logopenic variant would be eligible for lecanemab treatment.<\/jats:p>","DOI":"10.1002\/alz.13092","type":"journal-article","created":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T07:39:44Z","timestamp":1682581184000},"page":"5303-5304","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Don't forget primary progressive aphasia for anti\u2010amyloid drugs: An estimation of eligible patients from the Lausanne Memory Center registry"],"prefix":"10.1002","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3410-8266","authenticated-orcid":false,"given":"Alessa","family":"Hausmann","sequence":"first","affiliation":[{"name":"Leenaards Memory Center, Department of Clinical Neurosciences Centre Hospitalier Universitaire Vaudois and University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6745-0722","authenticated-orcid":false,"given":"Paolo Salvioni","family":"Chiabotti","sequence":"additional","affiliation":[{"name":"Leenaards Memory Center, Department of Clinical Neurosciences Centre Hospitalier Universitaire Vaudois and University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirco","family":"Nasuti","sequence":"additional","affiliation":[{"name":"Leenaards Memory Center, Department of Clinical Neurosciences Centre Hospitalier Universitaire Vaudois and University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Rouaud","sequence":"additional","affiliation":[{"name":"Leenaards Memory Center, Department of Clinical Neurosciences Centre Hospitalier Universitaire Vaudois and University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Allali","sequence":"additional","affiliation":[{"name":"Leenaards Memory Center, Department of Clinical Neurosciences Centre Hospitalier Universitaire Vaudois and University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,27]]},"reference":[{"key":"e_1_2_1_5_2_1","article-title":"Lecanemab in Early Alzheimer's disease","author":"Dyck CH","year":"2022","journal-title":"N Engl J Med"},{"key":"e_1_2_1_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(21)00066-1"},{"key":"e_1_2_1_5_4_1","unstructured":"WimoA J\u00f6nssonL JohanssonG WinbladB Lecanemab: The Price of a Breakthrough.2023Accessed February 17th 2023. 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