{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T14:02:07Z","timestamp":1792245727593,"version":"4.4.0"},"reference-count":14,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,4,18]],"date-time":"2023-04-18T00:00:00Z","timestamp":1681776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The second annual 5\u2010day workshop on Principles and Techniques for Improving Preclinical to Clinical Translation in Alzheimer's Disease Research was held October 7\u201311, 2019, at The Jackson Laboratory in Bar Harbor, Maine, USA, and included didactic lectures and hands\u2010on training. Participants represented a broad range of research across the Alzheimer's disease (AD) field, and varied in career stages from trainees and early stage investigators to established faculty, with attendance from the United States, Europe, and Asia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In line with the National Institutes of Health (NIH) initiative on rigor and reproducibility, the workshop aimed to address training gaps in preclinical drug screening by providing participants with the skills and knowledge required to perform pharmacokinetic, pharmacodynamics, and preclinical efficacy experiments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This innovative and comprehensive workshop provided training in fundamental skill sets for executing in vivo preclinical translational studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The success of this workship is expected to translate into practical skills that will enable\u00a0the goals of improving preclinical to clinical translational studies for AD.<\/jats:p><\/jats:sec><jats:sec><jats:title>HIGHLIGHTS<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Nearly all preclinical studies in animal models have failed to translate to successful efficacious medicines for Alzheimer's disease (AD) patients.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>While a wide variety of potential causes of these failures have been proposed,deficiencies in knowledge and best practices for translational research are not being sufficiently addressed by common training practices.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Here we present proceedings from an annual NIA\u2013sponsored workshop focused specifically on preclinical testing paradigms for AD translational research in animal models aimed at enabling improved preclinical to clinical translation for AD.<\/jats:p><\/jats:list-item><\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.13093","type":"journal-article","created":{"date-parts":[[2023,4,18]],"date-time":"2023-04-18T09:24:16Z","timestamp":1681809856000},"page":"5284-5288","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Meeting report of the annual workshop on Principles and Techniques for Improving Preclinical to Clinical Translation in Alzheimer's Disease research"],"prefix":"10.1002","volume":"19","author":[{"given":"Michael","family":"Sasner","sequence":"first","affiliation":[{"name":"The Jackson Laboratory  Bar Harbor Maine USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul R.","family":"Territo","sequence":"additional","affiliation":[{"name":"Indiana University School of Medicine Stark Neurosciences Research Institute  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey J.","family":"Sukoff Rizzo","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine \u2013 Aging Institute  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.12038"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/alzrt90"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.12110"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000410"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41231\u2010019\u20100050\u20107"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2016.00043"},{"key":"e_1_2_8_8_1","unstructured":"AlzPED\u2014Alzheimer's Preclinical Efficacy Database. 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