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We explored semantic fluency performance in DS and its relationship to age, AD, and blood biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 302 adults with DS at baseline and 87 at follow\u2010up from the London Down Syndrome Consortium cohort completed neuropsychological assessments. Blood biomarkers were measured with the single molecule array technique in a subset of 94 participants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Poorer verbal fluency performance was observed as age increases. Number of correct words declined in those with AD compared to those without over 2 years and was negatively correlated with neurofilament light (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a0\u20130.37,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.001) and glial fibrillary acidic protein (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a0\u20130.31,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.012).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Semantic fluency may be useful as an early indicator of cognitive decline and provide additional information on AD\u2010related change, showing associations with biomarkers in DS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.13097","type":"journal-article","created":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T08:51:59Z","timestamp":1682671919000},"page":"5129-5137","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Exploring semantic verbal fluency patterns and their relationship to age and Alzheimer's disease in adults with Down syndrome"],"prefix":"10.1002","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7059-3209","authenticated-orcid":false,"given":"Farah","family":"Mgaieth","sequence":"first","affiliation":[{"name":"Department of Forensic and Neurodevelopmental Sciences Institute of Psychiatry Psychology &amp; Neuroscience King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Asaad","family":"Baksh","sequence":"additional","affiliation":[{"name":"Department of Forensic and Neurodevelopmental Sciences Institute of Psychiatry Psychology &amp; Neuroscience King's College London  London UK"},{"name":"The LonDownS Consortium  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla M.","family":"Startin","sequence":"additional","affiliation":[{"name":"Department of Forensic and Neurodevelopmental Sciences Institute of Psychiatry Psychology &amp; Neuroscience King's College London  London UK"},{"name":"The LonDownS Consortium  London UK"},{"name":"Division of Psychiatry University College London  London UK"},{"name":"School of Psychology University of Roehampton  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Hamburg","sequence":"additional","affiliation":[{"name":"The LonDownS Consortium  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosalyn","family":"Hithersay","sequence":"additional","affiliation":[{"name":"Department of Forensic and Neurodevelopmental Sciences Institute of Psychiatry Psychology &amp; Neuroscience King's College London  London UK"},{"name":"The LonDownS Consortium  London UK"},{"name":"Division of Psychiatry University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Pape","sequence":"additional","affiliation":[{"name":"Department of Forensic and Neurodevelopmental Sciences Institute of Psychiatry Psychology &amp; Neuroscience King's College London  London UK"},{"name":"South London and Maudsley NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology the Sahlgrenska Academy at the University of Gothenburg  M\u00f6lndal Sweden"},{"name":"Clinical Neurochemistry Laboratory Sahlgrenska University Hospital  M\u00f6lndal Sweden"},{"name":"Department of Neurodegenerative Disease UCL Institute of Neurology  London UK"},{"name":"UK Dementia Research Institute at UCL  London UK"},{"name":"Hong Kong Center for Neurodegenerative Diseases  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"Ashton","sequence":"additional","affiliation":[{"name":"South London and Maudsley NHS Foundation Trust  London UK"},{"name":"Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology the Sahlgrenska Academy at the University of Gothenburg  M\u00f6lndal Sweden"},{"name":"Institute of Psychiatry Psychology and Neuroscience Maurice Wohl Institute Clinical Neuroscience Institute King's College London  London UK"},{"name":"Centre for Age\u2010Related Medicine Stavanger University Hospital  Stavanger Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miren","family":"Tamayo\u2010Elizalde","sequence":"additional","affiliation":[{"name":"Department of Forensic and Neurodevelopmental Sciences Institute of Psychiatry Psychology &amp; Neuroscience King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fedal","family":"Saini","sequence":"additional","affiliation":[{"name":"Department of Forensic and Neurodevelopmental Sciences Institute of Psychiatry Psychology &amp; Neuroscience King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Idris","sequence":"additional","affiliation":[{"name":"Department of Forensic and Neurodevelopmental Sciences Institute of Psychiatry Psychology &amp; Neuroscience King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"The LonDownS","family":"Consortium","sequence":"additional","affiliation":[{"name":"The LonDownS Consortium  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre","family":"Strydom","sequence":"additional","affiliation":[{"name":"Department of Forensic and Neurodevelopmental Sciences Institute of Psychiatry Psychology &amp; Neuroscience King's College London  London UK"},{"name":"The LonDownS Consortium  London UK"},{"name":"Division of Psychiatry University College London  London UK"},{"name":"South London and Maudsley NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2012.294"},{"key":"e_1_2_9_3_1","unstructured":"Foundation GDS.Facts and FAQ About Down Syndrome.2019. 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