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The association between retinal thickness and DTI measures was adjusted for age, sex, retinotopy, and correlation between eyes.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Optic tract mean diffusivity and axial diffusivity were negatively correlated with retinotopically defined ganglion cell inner plexiform thickness (GCIPL). Fractional anisotropy was negatively correlated with retinotopically defined retinal nerve fiber layer thickness. There was no correlation between outer nuclear layer (ONL) thickness and any DTI measure.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>In ADAD, GCIPL thickness is significantly associated with retinotopic optic tract DTI measures even in minimally symptomatic subjects. Similar associations were not present with ONL thickness or when ignoring retinotopy. We provide in vivo evidence for optic tract changes resulting from ganglion cell pathology in ADAD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.13100","type":"journal-article","created":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T04:16:28Z","timestamp":1682568988000},"page":"5103-5113","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Retinotopic degeneration of the retina and optic tracts in autosomal dominant Alzheimer's disease"],"prefix":"10.1002","volume":"19","author":[{"given":"Suman","family":"Adhikari","sequence":"first","affiliation":[{"name":"Wilmer Eye Institute Johns Hopkins University  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchuan","family":"Qiao","sequence":"additional","affiliation":[{"name":"Mark and Mary Stevens Neuroimaging and Informatics Institute Keck School of Medicine University of Southern California  Los Angeles California 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