{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T19:19:18Z","timestamp":1778959158571,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T00:00:00Z","timestamp":1682553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000864","name":"Michael J. Fox Foundation for Parkinson's Research","doi-asserted-by":"publisher","award":["MJFF\u2010021307"],"award-info":[{"award-number":["MJFF\u2010021307"]}],"id":[{"id":"10.13039\/100000864","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>INTRODUCTION<\/jats:title><jats:p>Accumulating evidence suggests that \u03b1\u2010synuclein (\u03b1Syn) can modulate Alzheimer's disease (AD) pathology. The aim of this study was to evaluate the prevalence and clinical features associated with cerebrospinal fluid (CSF) \u03b1Syn detected by seed amplification assay (SAA) in AD.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Eighty AD patients with CSF AT(N) biomarker positivity (mean age 70.3\u00a0\u00b1\u00a07.3 years) and 28 non\u2010AD age\u2010matched controls were included. All subjects underwent standardized clinical assessment; CSF \u03b1Syn aggregates were detected by SAA.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>CSF was \u03b1Syn\u2010SAA positive (\u03b1Syn+) in 36\/80 AD patients (45%) and in 2\/28 controls (7.1%). AD \u03b1Syn+ and \u03b1Syn\u2212 patients were comparable for age, disease severity, comorbidity profile, and CSF core biomarkers. AD \u03b1Syn+ presented a higher prevalence of atypical phenotypes and symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Our findings demonstrate that concomitant CSF \u03b1Syn pathology is present in a significant proportion of AD patients starting in the early stages and can affect clinical presentation. Longitudinal studies are warranted to evaluate the significance for the disease course.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.13109","type":"journal-article","created":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T07:29:42Z","timestamp":1682580582000},"page":"3754-3759","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["CSF alpha\u2010synuclein aggregates by seed amplification and clinical presentation of AD"],"prefix":"10.1002","volume":"19","author":[{"given":"Andrea","family":"Pilotto","sequence":"first","affiliation":[{"name":"Department of Clinical and Experimental Sciences, Neurology Unit University of Brescia  Brescia Italy"},{"name":"Department of Continuity of Care and Frailty, Neurology Unit ASST Spedali Civili Brescia Hospital Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matilde","family":"Bongianni","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Biomedicine and Movement Sciences University of Verona  Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clara","family":"Tirloni","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Sciences, Neurology Unit University of Brescia  Brescia Italy"},{"name":"Department of Continuity of Care and Frailty, Neurology Unit ASST Spedali Civili Brescia Hospital Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice","family":"Galli","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Sciences, Neurology Unit University of Brescia  Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Padovani","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Sciences, Neurology Unit University of Brescia  Brescia Italy"},{"name":"Department of Continuity of Care and Frailty, Neurology Unit ASST Spedali Civili Brescia Hospital Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluigi","family":"Zanusso","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Biomedicine and Movement Sciences University of Verona  Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,4,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awy146"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2015.0606"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-013-1157-y"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.338"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.50897"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-018-0508-2"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-020-02160-8"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcab045"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-020-0721-9"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/cts.12491"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004058"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26431"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-215646"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddu275"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1315200"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trci.2016.09.002"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-017-1717-7"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-019-0333-5"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.06.3053"},{"key":"e_1_2_8_21_1","first-page":"1","article-title":"High diagnostic performance of independent alpha\u2010synuclein seed amplification assays for detection of early Parkinson's disease","volume":"9","author":"Russo MJ","year":"2021","journal-title":"Acta Neuropathol Commun"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2017.01.014"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(20)30449-X"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awab005"}],"container-title":["Alzheimer's &amp; 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