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Evidence of adaptive immune cells responding to cerebral \u03b2\u2010amyloidosis has raised the question of whether immune markers could be used as proxies for \u03b2\u2010amyloid accumulation in the brain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Here, we apply multidimensional mass\u2010cytometry combined with unbiased machine\u2010learning techniques to immunophenotype peripheral blood mononuclear cells from a total of 251 participants in cross\u2010sectional and longitudinal studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>We show that increases in antigen\u2010experienced adaptive immune cells in the blood, particularly CD45RA\u2010reactivated T effector memory (TEMRA) cells, are associated with early accumulation of brain \u03b2\u2010amyloid and with changes in plasma AD biomarkers in still cognitively healthy subjects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Our results suggest that preclinical AD pathology is linked to systemic alterations of the adaptive immune system. These immunophenotype changes may help identify and develop novel diagnostic tools for early AD assessment and better understand clinical outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.13136","type":"journal-article","created":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T10:48:20Z","timestamp":1686739700000},"page":"5642-5662","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Early \u03b2\u2010amyloid accumulation in the brain is associated with peripheral T cell alterations"],"prefix":"10.1002","volume":"19","author":[{"given":"Christoph","family":"Gericke","sequence":"first","affiliation":[{"name":"Institute for Regenerative Medicine \u2013 IREM University of Zurich  Schlieren Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tunahan","family":"Kirabali","sequence":"additional","affiliation":[{"name":"Institute for Regenerative Medicine \u2013 IREM 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