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Expression levels for ADRP and DMN were measured in each subject and time point, and the resulting changes were correlated with cognitive performance. The role of network expression in predicting conversion to dementia was also evaluated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Longitudinal increases in ADRP expression were observed in converters, while age\u2010related DMN loss was seen in converters and nonconverters. Cognitive decline correlated with increases in ADRP and declines in DMN, but conversion to dementia was predicted only by baseline ADRP levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>The results point to the potential utility of ADRP as an imaging biomarker of AD progression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.13137","type":"journal-article","created":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T11:34:52Z","timestamp":1684496092000},"page":"4061-4072","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Longitudinal changes in metabolic network activity in early Alzheimer's disease"],"prefix":"10.1002","volume":"19","author":[{"given":"Matej","family":"Perovnik","sequence":"first","affiliation":[{"name":"Department of Neurology University Medical Center Ljubljana  Ljubljana Slovenia"},{"name":"Faculty of Medicine University of Ljubljana  Ljubljana Slovenia"},{"name":"Center for Neurosciences The Feinstein Institutes for Medical Research  Manhasset New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris C.","family":"Tang","sequence":"additional","affiliation":[{"name":"Center for Neurosciences The Feinstein Institutes for Medical Research  Manhasset New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Nam\u00edas","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Centro Diagn\u00f3stico Nuclear  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Eidelberg","sequence":"additional","affiliation":[{"name":"Center for Neurosciences The Feinstein Institutes for Medical Research  Manhasset New York USA"},{"name":"Molecular Medicine and Neurology Donald and Barbara Zucker School of Medicine at Hofstra\/Northwell  Hempstead New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Alzheimer's Disease Neuroimaging Initiative (ADNI)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13439"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.018"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-021-00529-1"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.01.056"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-022-00753-3"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003285"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.2174\/156720501108140910114230"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-31653-6"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-15667-9"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.10.025"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.1005731"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1440.011"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-021-00474-4"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01150-x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1411011112"},{"key":"e_1_2_9_17_1","unstructured":"The ADNI team. 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