{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T13:19:20Z","timestamp":1789996760452,"version":"4.0.1"},"reference-count":43,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T00:00:00Z","timestamp":1685664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007625","name":"Cure Alzheimer's Fund","doi-asserted-by":"publisher","award":["282952"],"award-info":[{"award-number":["282952"]}],"id":[{"id":"10.13039\/100007625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013263","name":"Nasjonalforeningen for Folkehelsen","doi-asserted-by":"publisher","award":["22679"],"award-info":[{"award-number":["22679"]}],"id":[{"id":"10.13039\/501100013263","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>INTRODUCTION<\/jats:title><jats:p>The kynurenine pathway's (KP) malfunction is closely related to Alzheimer's disease (AD), for antagonistic kynurenic acid (KA) and agonistic quinolinic acid act on the <jats:italic>N<\/jats:italic>\u2010methyl\u2010D\u2010aspartate receptor, a possible therapeutic target in treating AD.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>In our longitudinal case\u2013control study, KP metabolites in the cerebrospinal fluid were analyzed in 311 patients with AD and 105 cognitively unimpaired controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Patients with AD exhibited higher concentrations of KA (\u03b2\u00a0=\u00a00.18, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01) and picolinic acid (\u03b2\u00a0=\u00a00.20, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01) than the controls. KA was positively associated with tau pathology (\u03b2\u00a0=\u00a00.29, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01), and a higher concentration of KA was associated with the slower progression of dementia.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>The higher concentrations of neuroprotective metabolites KA and picolinic acid suggest that the activation of the KP's neuroprotective branch is an adaptive response in AD and may be a promising target for intervention and treatment.<\/jats:p><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Patients with Alzheimer's disease (AD) exhibited higher concentrations of kynurenic acid and picolinic acid than controls.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Higher concentrations of kynurenic acid were associated with slower progression of AD.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Potential neurotoxic kynurenines were not increased among patients with AD.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Activation of the kynurenine pathway's neuroprotective branch may be an adaptive response in AD.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><\/jats:sec>","DOI":"10.1002\/alz.13162","type":"journal-article","created":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T10:02:44Z","timestamp":1685700164000},"page":"5573-5582","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Higher concentrations of kynurenic acid in CSF are associated with the slower clinical progression of Alzheimer's disease"],"prefix":"10.1002","volume":"19","author":[{"given":"Anne\u2010Brita","family":"Knapskog","sequence":"first","affiliation":[{"name":"Department of Geriatric Medicine Oslo University Hospital  Oslo 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