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We investigated the influence of food intake on AD\u2010related biomarkers in cognitively healthy, obese adults at high metabolic risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>One\u2010hundred eleven participants underwent repeated blood sampling during 3 h after a standardized meal (postprandial group, PG). For comparison, blood was sampled from a fasting subgroup over 3 h (fasting group, FG). Plasma neurofilament light (NfL), glial fibrillary acidic protein (GFAP), amyloid\u2010beta (A\u03b2) 42\/40, phosphorylated tau (p\u2010tau) 181 and 231, and total\u2010tau were measured via single molecule array assays.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Significant differences were found for NfL, GFAP, A\u03b242\/40, p\u2010tau181, and p\u2010tau231 between FG and PG. The greatest change to baseline occurred for GFAP and p\u2010tau181 (120\u00a0min postprandially,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Our data suggest that AD\u2010related biomarkers are altered by food intake. Further studies are needed to verify whether blood biomarker sampling should be performed in the fasting state.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Acute food intake alters plasma biomarkers of Alzheimer's disease in obese, otherwise healthy adults.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>We also found dynamic fluctuations in plasma biomarkers concentration in the fasting state suggesting physiological diurnal variations.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Further investigations are highly needed to verify if biomarker measurements should be performed in the fasting state and at a standardized time of day to improve the diagnostic accuracy.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.13163","type":"journal-article","created":{"date-parts":[[2023,5,27]],"date-time":"2023-05-27T10:04:16Z","timestamp":1685181856000},"page":"5531-5540","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Levels of Alzheimer's disease blood biomarkers are altered after food intake\u2014A pilot intervention study in healthy adults"],"prefix":"10.1002","volume":"19","author":[{"given":"Hanna","family":"Huber","sequence":"first","affiliation":[{"name":"Nutritional Physiology Institute of Nutrition and Food Science University of Bonn  Bonn Germany"},{"name":"Nutrition and Microbiota Institute of Nutrition and Food Science University of Bonn  Bonn 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