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Baseline flortaucipir levels, amyloid beta (A\u03b2) positivity, and clinical variables, identified moderate and fast accumulators with 81% and 95% positive predictive values, respectively. Screening for fast tau accumulation and A\u03b2 positivity in early Alzheimer's disease, compared to A\u03b2 positivity with variable tau progression profiles, required 46% to 77% lower sample size to achieve 80% power for 30% slowing of clinical decline.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>Predicting tau progression with baseline imaging and clinical markers could allow screening of high\u2010risk individuals most likely to benefit from a specific treatment regimen.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.13164","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T07:00:16Z","timestamp":1686207616000},"page":"5605-5619","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Profiling and predicting distinct tau progression patterns: An unsupervised data\u2010driven approach to flortaucipir positron emission tomography"],"prefix":"10.1002","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8644-7724","authenticated-orcid":false,"given":"Duygu","family":"Tosun","sequence":"first","affiliation":[{"name":"Department of Radiology and Biomedical Imaging University of California San Francisco  San Francisco California USA"},{"name":"Northern California Institute of Research and Education  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela","family":"Thropp","sequence":"additional","affiliation":[{"name":"Northern California Institute of Research and Education  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudeepti","family":"Southekal","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce","family":"Spottiswoode","sequence":"additional","affiliation":[{"name":"Siemens Medical Solutions USA, Inc. 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