{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T13:00:45Z","timestamp":1779195645052,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"S9","license":[{"start":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T00:00:00Z","timestamp":1686268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U24 AG072122"],"award-info":[{"award-number":["U24 AG072122"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R56AG057195"],"award-info":[{"award-number":["R56AG057195"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U01AG057195"],"award-info":[{"award-number":["U01AG057195"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U24AG021886"],"award-info":[{"award-number":["U24AG021886"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>We examined neuropsychiatric symptoms (NPS) and psychotropic medication use in a large sample of individuals with early\u2010onset Alzheimer's disease (EOAD; onset 40\u201064 years) at the midway point of data collection for the Longitudinal Early\u2010onset Alzheimer's Disease Study (LEADS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Baseline NPS (Neuropsychiatric Inventory \u2013 Questionnaire; Geriatric Depression Scale) and psychotropic medication use from 282 participants enrolled in LEADS were compared across diagnostic groups \u2013 amyloid\u2010positive EOAD (<jats:italic>n<\/jats:italic>\u00a0=\u00a0212) and amyloid negative early\u2010onset non\u2010Alzheimer's disease (EOnonAD; <jats:italic>n<\/jats:italic>\u00a0=\u00a070).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Affective behaviors were the most common NPS in EOAD at similar frequencies to EOnonAD. Tension and impulse control behaviors were more common in EOnonAD. A minority of participants were using psychotropic medications, and use was higher in EOnonAD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Overall NPS burden and psychotropic medication use were higher in EOnonAD than EOAD participants. Future research will investigate moderators and etiological drivers of NPS, and NPS differences in EOAD versus late\u2010onset AD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.13344","type":"journal-article","created":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T22:40:04Z","timestamp":1686350404000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Baseline neuropsychiatric symptoms and psychotropic medication use midway through data collection of the Longitudinal Early\u2010Onset Alzheimer's Disease Study (LEADS) cohort"],"prefix":"10.1002","volume":"19","author":[{"given":"Angelina J.","family":"Polsinelli","sequence":"first","affiliation":[{"name":"Department of Neurology Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan J.","family":"Wonderlin","sequence":"additional","affiliation":[{"name":"Marian University College of 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