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BPV was not significantly associated with dementia.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>Findings suggest that cumulative BP over the course of midlife predicts risk of dementia in later life.<\/jats:p><jats:sec><jats:title>HIGHLIGHTS<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Long\u2010term blood pressure (BP) patterns are strong indicators of vascular risks.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Cumulative BP and BP variability (BPV) were used to reflect BP patterns across midlife.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>High cumulative BP in midlife is associated with increased dementia risk.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Visit\u2010to\u2010visit BPV was not associated with the onset of 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